Darryl A Knight
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Explore the profile of Darryl A Knight including associated specialties, affiliations and a list of published articles.
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136
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5083
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Recent Articles
1.
Liu G, Hsu A, Geirnaert S, Cong C, Nair P, Shen S, et al.
Mol Ther
. 2025 Jan;
33(3):917-932.
PMID: 39838644
Vitronectin (VTN) is an important extracellular matrix protein in tissue remodeling, but its role in chronic obstructive pulmonary disease (COPD) is unknown. We show that VTN regulates tissue remodeling through...
2.
Read J, Reid A, Thomson C, Plit M, Mejia R, Knight D, et al.
Clin Sci (Lond)
. 2024 Apr;
138(8):537-554.
PMID: 38577922
Patients with pulmonary fibrosis (PF) often experience exacerbations of their disease, characterised by a rapid, severe deterioration in lung function that is associated with high mortality. Whilst the pathobiology of...
3.
Veerati P, Reid A, Nichol K, Wark P, Knight D, Bartlett N, et al.
Am J Physiol Lung Cell Mol Physiol
. 2023 Jun;
325(2):L206-L214.
PMID: 37280545
Bronchoconstriction is the main physiological event in asthma, which leads to worsened clinical symptoms and generates mechanical stress within the airways. Virus infection is the primary cause of exacerbations in...
4.
Blokland K, Nizamoglu M, Habibie H, Borghuis T, Schuliga M, Melgert B, et al.
Front Pharmacol
. 2022 Nov;
13:989169.
PMID: 36408252
In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes can have a major impact on cell functions including proliferation, secretory profile and differentiation. Several studies...
5.
Veerati P, Nichol K, Read J, Bartlett N, Wark P, Knight D, et al.
Am J Physiol Lung Cell Mol Physiol
. 2022 Aug;
323(4):L495-L502.
PMID: 36041223
Primary bronchial epithelial cells (pBECs) obtained from donors have limited proliferation capacity. Recently, conditional reprogramming (CR) technique has overcome this and has provided the potential for extended passaging and subsequent...
6.
Prele C, Miles T, Pearce D, ODonoghue R, Grainge C, Barrett L, et al.
Eur Respir J
. 2022 Jul;
60(5).
PMID: 35798357
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis...
7.
Tu X, Kim R, Brown A, de Jong E, Jones-Freeman B, Ali M, et al.
J Allergy Clin Immunol
. 2022 Jun;
150(4):817-829.e6.
PMID: 35643377
Background: Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap (ACO). Patients characterized with ACO have increased...
8.
Williams T, Loo S, Nichol K, Reid A, Veerati P, Esneau C, et al.
Commun Biol
. 2022 May;
5(1):415.
PMID: 35508632
IL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated. We observed abundant expression and colocalization of...
9.
Iosifidis T, Sutanto E, Montgomery S, Agudelo-Romero P, Looi K, Ling K, et al.
J Pers Med
. 2021 Dec;
11(12).
PMID: 34945795
The airway epithelium of children with wheeze is characterized by defective repair that contributes to disease pathobiology. Dysregulation of developmental processes controlled by Notch has been identified in chronic asthma....
10.
Waters D, Schuliga M, Pathinayake P, Wei L, Tan H, Blokland K, et al.
Biomedicines
. 2021 Sep;
9(9).
PMID: 34572347
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies...