Till Bretschneider
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Explore the profile of Till Bretschneider including associated specialties, affiliations and a list of published articles.
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39
Citations
1136
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Recent Articles
1.
Kay R, Lutton J, King J, Bretschneider T
Biochem Soc Trans
. 2024 Jun;
52(4):1785-1794.
PMID: 38934501
Macropinocytosis is a broadly conserved endocytic process discovered nearly 100 years ago, yet still poorly understood. It is prominent in cancer cell feeding, immune surveillance, uptake of RNA vaccines and...
2.
Lutton J, Coker H, Paschke P, Munn C, King J, Bretschneider T, et al.
Curr Biol
. 2023 Jun;
33(15):3083-3096.e6.
PMID: 37379843
Macropinocytosis is a conserved endocytic process by which cells engulf droplets of medium into micron-sized vesicles. We use light-sheet microscopy to define an underlying set of principles by which macropinocytic...
3.
Platt A, Lutton E, Offord E, Bretschneider T
Bioinformatics
. 2023 Jan;
39(1).
PMID: 36629475
Summary: Advances in 3D live cell microscopy are enabling high-resolution capture of previously unobserved processes. Unleashing the power of modern machine learning methods to fully benefit from these technologies is,...
4.
Kay R, Lutton J, Coker H, Paschke P, King J, Bretschneider T
Subcell Biochem
. 2022 Apr;
98:41-59.
PMID: 35378702
Macropinocytosis is a relatively unexplored form of large-scale endocytosis driven by the actin cytoskeleton. Dictyostelium amoebae form macropinosomes from cups extended from the plasma membrane, then digest their contents and...
5.
Lutton E, Collier S, Bretschneider T
IEEE Trans Med Imaging
. 2020 Oct;
40(2):514-526.
PMID: 33052849
High-resolution 3D microscopy is a fast advancing field and requires new techniques in image analysis to handle these new datasets. In this work, we focus on detailed 3D segmentation of...
6.
Stinner B, Bretschneider T
Biochem Soc Trans
. 2020 Apr;
48(2):419-428.
PMID: 32239187
Directed cell migration poses a rich set of theoretical challenges. Broadly, these are concerned with (1) how cells sense external signal gradients and adapt; (2) how actin polymerisation is localised...
7.
Baniukiewicz P, Collier S, Bretschneider T
Bioinformatics
. 2018 Mar;
34(15):2695-2697.
PMID: 29566132
Summary: Transmembrane signalling plays important physiological roles, with G protein-coupled cell surface receptors being particularly important therapeutic targets. Fluorescent proteins are widely used to study signalling, but analyses of image...
8.
Collier S, Paschke P, Kay R, Bretschneider T
Sci Rep
. 2017 Jul;
7(1):6692.
PMID: 28751725
Cells often employ fast, pressure-driven blebs to move through tissues or against mechanical resistance, but how bleb sites are selected and directed to the cell front remains an open question....
9.
Cvijovic M, Hofer T, Acimovic J, Alberghina L, Almaas E, Besozzi D, et al.
NPJ Syst Biol Appl
. 2017 Jul;
2:16011.
PMID: 28725471
Systems Biology is an approach to biology and medicine that has the potential to lead to a better understanding of how biological properties emerge from the interaction of genes, proteins,...
10.
Bretschneider T, Othmer H, Weijer C
Interface Focus
. 2016 Oct;
6(5):20160047.
PMID: 27708767
Movement of cells and tissues is a basic biological process that is used in development, wound repair, the immune response to bacterial invasion, tumour formation and metastasis, and the search...