Tibor Rohacs
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Explore the profile of Tibor Rohacs including associated specialties, affiliations and a list of published articles.
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81
Citations
3780
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Recent Articles
1.
Gabrielle M, Yudin Y, Wang Y, Su X, Rohacs T
Nat Commun
. 2024 Aug;
15(1):7020.
PMID: 39147733
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown...
2.
Gabrielle M, Yudin Y, Wang Y, Su X, Rohacs T
bioRxiv
. 2024 Mar;
PMID: 38464030
Mechanosensitive PIEZO2 ion channels play roles in touch, proprioception, and inflammatory pain. Currently, there are no small molecule inhibitors that selectively inhibit PIEZO2 over PIEZO1. The TMEM120A protein was shown...
3.
Pumroy R, De Jesus-Perez J, Protopopova A, Rocereta J, Fluck E, Fricke T, et al.
EMBO Rep
. 2024 Jan;
25(2):506-523.
PMID: 38225355
Transient receptor potential vanilloid (TRPV) channels play a critical role in calcium homeostasis, pain sensation, immunological response, and cancer progression. TRPV channels are blocked by ruthenium red (RR), a universal...
4.
De Jesus-Perez J, Gabrielle M, Raheem S, Fluck E, Rohacs T, Moiseenkova-Bell V
Structure
. 2023 Dec;
32(2):148-156.e5.
PMID: 38141613
The calcium-selective TRPV5 channel activated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P] is involved in calcium homeostasis. Recently, cryoelectron microscopy (cryo-EM) provided molecular details of TRPV5 modulation by exogenous and endogenous molecules. However,...
5.
Rohacs T
Annu Rev Physiol
. 2023 Oct;
86:329-355.
PMID: 37871124
Transient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and...
6.
Lee B, De Jesus Perez J, Moiseenkova-Bell V, Rohacs T
Nat Commun
. 2023 Sep;
14(1):5883.
PMID: 37735536
Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays important cellular regulatory roles, including activation and inhibition of ion channels. The structural basis of ion channel regulation by...
7.
Gabrielle M, Rohacs T
Channels (Austin)
. 2023 Jul;
17(1):2237306.
PMID: 37523628
TMEM120A (TACAN) is an enigmatic protein with several seemingly unconnected functions. It was proposed to be an ion channel involved in sensing mechanical stimuli, and knockdown/knockout experiments have implicated that...
8.
Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, et al.
Elife
. 2023 Jan;
12.
PMID: 36648066
TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in were identified in individuals with...
9.
Zhao S, Carnevale V, Gabrielle M, Gianti E, Rohacs T
J Biol Chem
. 2022 Oct;
298(11):102547.
PMID: 36181791
Transient receptor potential melastatin 3 (TRPM3) is a heat-activated ion channel expressed in peripheral sensory neurons and the central nervous system. TRPM3 activity depends on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate...
10.
Rohacs T, Fluck E, De Jesus-Perez J, Moiseenkova-Bell V
Cell Calcium
. 2022 Jul;
106:102620.
PMID: 35834842
Transient Receptor Potential Vanilloid 5 and 6 (TRPV5 and TRPV6) are Ca selective epithelial ion channels. They are the products of a relatively recent gene duplication in mammals, and have...