Tian-Le Xu
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Explore the profile of Tian-Le Xu including associated specialties, affiliations and a list of published articles.
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159
Citations
3277
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Recent Articles
1.
Lin Z, Gu X, Gong W, Wang M, Wu Y, Wang Q, et al.
J Clin Invest
. 2024 Sep;
134(22).
PMID: 39316444
Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging owing to the fragile nature of fear extinction, for which the ventral hippocampal CA1 (vCA1) region is considered as a central...
2.
Guo S, Gong Y, Zhang T, Su X, Wu Y, Yan Y, et al.
Sci Adv
. 2024 Aug;
10(33):eadn6272.
PMID: 39150998
Chronic itch often clinically coexists with anxiety symptoms, creating a vicious cycle of itch-anxiety comorbidities that are difficult to treat. However, the neuronal circuit mechanisms underlying the comorbidity of anxiety...
3.
Lai K, Pritisanac I, Liu Z, Liu H, Gong L, Li M, et al.
Nature
. 2024 Jul;
631(8022):826-834.
PMID: 38987597
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-D-aspartate receptor)-dependent cell death pathways in stroke, but unsuccessful clinical trials with NMDAR antagonists implicate the engagement of other...
4.
Huang C, Sun P, Jiang Y, Liu Y, Liu Z, Han S, et al.
Nat Commun
. 2024 Jun;
15(1):5288.
PMID: 38902277
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation through...
5.
Cheung H, Yu T, Yi X, Wu Y, Wang Q, Gu X, et al.
Commun Biol
. 2024 Jun;
7(1):728.
PMID: 38877285
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we reveal its impact on the thalamic nucleus...
6.
Wang J, Yang Q, Liu X, Li J, Wen Y, Hu Y, et al.
Nat Commun
. 2024 May;
15(1):4013.
PMID: 38740778
Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear...
7.
Wu X, Zhu X, Pan Y, Gu X, Liu X, Chen S, et al.
Aging Cell
. 2024 May;
23(8):e14187.
PMID: 38716507
Behavioral changes or neuropsychiatric symptoms (NPSs) are common features in dementia and are associated with accelerated cognitive impairment and earlier deaths. However, how NPSs are intertwined with cognitive decline remains...
8.
Zeng K, Jiao Z, Jiang Q, He R, Zhang Y, Li W, et al.
ACS Cent Sci
. 2024 Jan;
10(1):163-175.
PMID: 38292609
Light provides high temporal precision for neuronal modulations. Small molecules are advantageous for neuronal modulation due to their structural diversity, allowing them to suit versatile targets. However, current optochemical methods...
9.
An R, Lu C, Wang C, Chang L, Huang J, Jiang F, et al.
Neurosci Bull
. 2023 Nov;
40(1):133-138.
PMID: 37914957
No abstract available.
10.
Pan Q, Guo S, Chen M, Su X, Gao Z, Wang Q, et al.
Neuron
. 2023 May;
111(15):2414-2431.e7.
PMID: 37224813
Pain and itch are two closely related but essentially distinct sensations that elicit different behavioral responses. However, it remains mysterious how pain and itch information is encoded in the brain...