Thorsten E Boroviak
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Explore the profile of Thorsten E Boroviak including associated specialties, affiliations and a list of published articles.
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15
Citations
211
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Recent Articles
1.
Weberling A, Siriwardena D, Penfold C, Christodoulou N, Boroviak T, Zernicka-Goetz M
iScience
. 2025 Jan;
28(1):111671.
PMID: 39868030
The implantation of the mouse blastocyst initiates a complex sequence of tissue remodeling and cell differentiation events required for morphogenesis, during which the extraembryonic primitive endoderm transitions into the visceral...
2.
Siriwardena D, Munger C, Penfold C, Kohler T, Weberling A, Linneberg-Agerholm M, et al.
Cell Stem Cell
. 2024 Sep;
31(10):1427-1446.e8.
PMID: 39321797
Early human trophoblast development has remained elusive due to the inaccessibility of the early conceptus. Non-human primate models recapitulate many features of human development and allow access to early postimplantation...
3.
Dittrich M, Bernhardt L, Penfold C, Boroviak T, Drummer C, Behr R, et al.
Aging Cell
. 2024 May;
23(8):e14200.
PMID: 38757354
The sperm epigenome is thought to affect the developmental programming of the resulting embryo, influencing health and disease in later life. Age-related methylation changes in the sperm of old fathers...
4.
Kohler T, De Jonghe J, Ellermann A, Yanagida A, Herger M, Slatery E, et al.
Nat Commun
. 2023 Jul;
14(1):4022.
PMID: 37419903
Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-implantation development. Here,...
5.
Castillo-Venzor A, Penfold C, Morgan M, Tang W, Kobayashi T, Wong F, et al.
Life Sci Alliance
. 2023 May;
6(8).
PMID: 37217306
Human germline-soma segregation occurs during weeks 2-3 in gastrulating embryos. Although direct studies are hindered, here, we investigate the dynamics of human primordial germ cell (PGCs) specification using in vitro...
6.
Sheng G, Boroviak T, Schmidt-Ott U, Srinivas S
Philos Trans R Soc Lond B Biol Sci
. 2022 Oct;
377(1865):20210250.
PMID: 36252213
No abstract available.
7.
Siriwardena D, Boroviak T
Philos Trans R Soc Lond B Biol Sci
. 2022 Oct;
377(1865):20210256.
PMID: 36252209
Implantation of the conceptus into the uterus is absolutely essential for successful embryo development. In humans, our understanding of this process has remained rudimentary owing to the inaccessibility of early...
8.
Munger C, Kohler T, Slatery E, Ellermann A, Bergmann S, Penfold C, et al.
Development
. 2022 Sep;
149(20).
PMID: 36125063
The early specification and rapid growth of extraembryonic membranes are distinctive hallmarks of primate embryogenesis. These complex tasks are resolved through an intricate combination of signals controlling the induction of...
9.
Chen Y, Siriwardena D, Penfold C, Pavlinek A, Boroviak T
Development
. 2022 Jul;
149(13).
PMID: 35792865
The trophoblast lineage safeguards fetal development by mediating embryo implantation, immune tolerance, nutritional supply and gas exchange. Human trophoblast stem cells (hTSCs) provide a platform to study lineage specification of...
10.
Malkowska A, Penfold C, Bergmann S, Boroviak T
Nat Commun
. 2022 Jun;
13(1):3407.
PMID: 35710749
Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation to balance the generation of biomass with energy production. However, the dynamics of metabolic regulation in the postimplantation embryo in vivo have...