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Christopher Penfold

Explore the profile of Christopher Penfold including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 15
Citations 286
Followers 0
Related Specialties
General Medicine
General Surgery
Biology
Top 10 Co-Authors
Steven Thomas
Thorsten E Boroviak
Andrew R Ness
Stephen J Lewis
Dylan Siriwardena
Henning Keinke Andersen
Miranda Pring
Georgia Herbert
Charlotte Atkinson
Rachel Perry
Published In
Cochrane Database Syst Rev
Head Neck
Org Biomol Chem
Development
iScience
Affiliations
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Recent Articles
1.
Primitive to visceral endoderm maturation is essential for mouse epiblast survival beyond implantation
Weberling A, Siriwardena D, Penfold C, Christodoulou N, Boroviak T, Zernicka-Goetz M
iScience . 2025 Jan; 28(1):111671. PMID: 39868030
The implantation of the mouse blastocyst initiates a complex sequence of tissue remodeling and cell differentiation events required for morphogenesis, during which the extraembryonic primitive endoderm transitions into the visceral...
2.
Marmoset and human trophoblast stem cells differ in signaling requirements and recapitulate divergent modes of trophoblast invasion
Siriwardena D, Munger C, Penfold C, Kohler T, Weberling A, Linneberg-Agerholm M, et al.
Cell Stem Cell . 2024 Sep; 31(10):1427-1446.e8. PMID: 39321797
Early human trophoblast development has remained elusive due to the inaccessibility of the early conceptus. Non-human primate models recapitulate many features of human development and allow access to early postimplantation...
3.
mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells
Kubiura-Ichimaru M, Penfold C, Kojima K, Dollet C, Yabukami H, Semi K, et al.
Stem Cell Reports . 2023 Sep; 18(10):1987-2002. PMID: 37683645
Primate germ cell development remains largely unexplored due to limitations in sample collection and the long duration of development. In mice, primordial germ cell-like cells (PGCLCs) derived from pluripotent stem...
4.
An integrated atlas of human placental development delineates essential regulators of trophoblast stem cells
Chen Y, Siriwardena D, Penfold C, Pavlinek A, Boroviak T
Development . 2022 Jul; 149(13). PMID: 35792865
The trophoblast lineage safeguards fetal development by mediating embryo implantation, immune tolerance, nutritional supply and gas exchange. Human trophoblast stem cells (hTSCs) provide a platform to study lineage specification of...
5.
A hexa-species transcriptome atlas of mammalian embryogenesis delineates metabolic regulation across three different implantation modes
Malkowska A, Penfold C, Bergmann S, Boroviak T
Nat Commun . 2022 Jun; 13(1):3407. PMID: 35710749
Mammalian embryogenesis relies on glycolysis and oxidative phosphorylation to balance the generation of biomass with energy production. However, the dynamics of metabolic regulation in the postimplantation embryo in vivo have...
6.
Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells
Lawrence M, Shahsavari A, Bornelov S, Moreau T, McDonald R, Vallance T, et al.
Sci Adv . 2022 Feb; 8(7):eabj8618. PMID: 35171685
Platelet deficiency, known as thrombocytopenia, can cause hemorrhage and is treated with platelet transfusions. We developed a system for the production of platelet precursor cells, megakaryocytes, from pluripotent stem cells....
7.
Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications
Herbert G, Perry R, Andersen H, Atkinson C, Penfold C, Lewis S, et al.
Cochrane Database Syst Rev . 2019 Jul; 7:CD004080. PMID: 31329285
Background: This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth',...
8.
Dietary behaviors and survival in people with head and neck cancer: Results from Head and Neck 5000
Lang S, Schimansky S, Beynon R, Penfold C, Davies A, Waylen A, et al.
Head Neck . 2019 Jan; 41(7):2074-2084. PMID: 30698303
Background: The association between diet and head and neck cancer (HNC) survival is unclear. Methods: Cox proportional hazard models measured the association between fruit, vegetable, and deep-fried food intake and...
9.
Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000
Schimansky S, Lang S, Beynon R, Penfold C, Davies A, Waylen A, et al.
Head Neck . 2018 Dec; 41(4):1053-1062. PMID: 30549147
Background: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer. Methods: Survival analyses...
10.
Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications
Herbert G, Perry R, Andersen H, Atkinson C, Penfold C, Lewis S, et al.
Cochrane Database Syst Rev . 2018 Oct; 10:CD004080. PMID: 30353940
Background: This is an update of the review last published in 2011. It focuses on early postoperative enteral nutrition after lower gastrointestinal surgery. Traditional management consisted of 'nil by mouth',...