Thomas Spruce
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Explore the profile of Thomas Spruce including associated specialties, affiliations and a list of published articles.
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10
Citations
551
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Recent Articles
1.
Spruce T, Plass M, Gohr A, Ray D, Martinez de Lagran M, Rot G, et al.
PLoS Biol
. 2022 Apr;
20(4):e3001615.
PMID: 35476669
Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that Mbnl3 has undergone a...
2.
Gentsch G, Spruce T, Owens N, Smith J
Nat Commun
. 2019 Sep;
10(1):4269.
PMID: 31537794
Embryonic development yields many different cell types in response to just a few families of inductive signals. The property of signal-receiving cells that determines how they respond to inductive signals...
3.
Gentsch G, Spruce T, Owens N, Monteiro R, Smith J
Dev Cell
. 2019 May;
49(4):506-507.
PMID: 31112697
No abstract available.
4.
Gentsch G, Spruce T, Monteiro R, Owens N, Martin S, Smith J
Dev Cell
. 2018 Feb;
44(5):597-610.e10.
PMID: 29478923
Antisense morpholino oligomers (MOs) have been indispensable tools for developmental biologists to transiently knock down (KD) genes rather than to knock them out (KO). Here we report on the implications...
5.
MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM
Pernaute B, Spruce T, Smith K, Sanchez-Nieto J, Manzanares M, Cobb B, et al.
Genes Dev
. 2014 Sep;
28(17):1873-8.
PMID: 25184675
Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely...
6.
Pernaute B, Spruce T, Rodriguez T, Manzanares M
Cell Cycle
. 2011 Feb;
10(4):584-91.
PMID: 21293181
At the time of implantation the mouse embryo is composed of three tissues the epiblast, trophectoderm and primitive endoderm. As development progresses the epiblast goes on to form the foetus...
7.
Spruce T, Pernaute B, Di-Gregorio A, Cobb B, Merkenschlager M, Manzanares M, et al.
Dev Cell
. 2010 Aug;
19(2):207-19.
PMID: 20708584
The two first cell fate decisions taken in the mammalian embryo generate three distinct cell lineages: one embryonic, the epiblast, and two extraembryonic, the trophoblast and primitive endoderm. miRNAs are...
8.
Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, et al.
Cell
. 2010 Jul;
141(7):1195-207.
PMID: 20603000
Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain...
9.
Santos J, Pereira C, Di-Gregorio A, Spruce T, Alder O, Rodriguez T, et al.
Epigenetics Chromatin
. 2010 Feb;
3:1.
PMID: 20157423
Background: During early mouse development, two extra-embryonic lineages form alongside the future embryo: the trophectoderm (TE) and the primitive endoderm (PrE). Epigenetic changes known to take place during these early...
10.
Nesterova T, Popova B, Cobb B, Norton S, Senner C, Tang Y, et al.
Epigenetics Chromatin
. 2008 Nov;
1(1):2.
PMID: 19014663
Background: X chromosome inactivation is the mechanism used in mammals to achieve dosage compensation of X-linked genes in XX females relative to XY males. Chromosome silencing is triggered in cis...