Miguel Manzanares
Overview
Explore the profile of Miguel Manzanares including associated specialties, affiliations and a list of published articles.
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Articles
55
Citations
2467
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Recent Articles
1.
Carreno-Tarragona G, Tiana M, Rouco R, Leivas A, Victorino J, Garcia-Vicente R, et al.
Blood
. 2025 Feb;
PMID: 39919265
Although described more than a decade ago, the mechanism by which the JAK2 46/1 haplotype increases the risk of developing JAK2-mutated myeloproliferative neoplasms (MPN) remains unexplained. Inflammation and immunity are...
2.
Linneberg-Agerholm M, Sell A, Redo-Riveiro A, Perera M, Proks M, Knudsen T, et al.
Cell
. 2024 Jun;
187(15):4010-4029.e16.
PMID: 38917790
Mammalian blastocyst formation involves the specification of the trophectoderm followed by the differentiation of the inner cell mass into embryonic epiblast and extra-embryonic primitive endoderm (PrE). During this time, the...
3.
Gimenez-Llorente D, Portela M, Losada A, Manzanares M, Andreu M
STAR Protoc
. 2023 May;
4(2):102267.
PMID: 37126445
Hi-C studies the three-dimensional structure of the genome by detecting genome-wide chromatin regions that are in spatial proximity within the nucleus. We developed single-blastocyst Hi-C in mutant mouse embryos to...
4.
Andreu M, Alvarez-Franco A, Portela M, Gimenez-Llorente D, Cuadrado A, Badia-Careaga C, et al.
Cell Rep
. 2022 Oct;
41(3):111501.
PMID: 36260992
The eukaryotic genome is organized in 3D at different scales. This structure is driven and maintained by different chromatin states and by architectural factors, such as the zinc finger protein...
5.
Portela M, Jimenez-Carretero D, Labrador V, Andreu M, Arza E, Caiolfa V, et al.
Biol Open
. 2022 Jul;
11(8).
PMID: 35876820
Most studies addressing chromatin behaviour during preimplantation development are based on biochemical assays that lack spatial and cell-specific information, crucial during early development. Here, we describe the changes in chromatin...
6.
Tiana M, Lopez-Jimenez E, de Aja J, Barral A, Victorino J, Badia-Careaga C, et al.
Sci Adv
. 2022 Jul;
8(28):eabo3583.
PMID: 35857513
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are...
7.
Bleckwehl T, Crispatzu G, Schaaf K, Respuela P, Bartusel M, Benson L, et al.
Nat Commun
. 2021 Oct;
12(1):5771.
PMID: 34599190
Germline specification in mammals occurs through an inductive process whereby competent cells in the post-implantation epiblast differentiate into primordial germ cells (PGC). The intrinsic factors that endow epiblast cells with...
8.
Alvarez-Franco A, Rouco R, Ramirez R, Guerrero-Serna G, Tiana M, Cogliati S, et al.
Cardiovasc Res
. 2021 Jul;
117(11):2353.
PMID: 34254112
No abstract available.
9.
Victorino J, Alvarez-Franco A, Manzanares M
J Mol Cell Cardiol
. 2021 Apr;
157:45-55.
PMID: 33887329
Atrial fibrillation is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. Despite years of study, we still do not have a full comprehension of...
10.
Alvarez-Franco A, Rouco R, Ramirez R, Guerrero-Serna G, Tiana M, Cogliati S, et al.
Cardiovasc Res
. 2020 Oct;
117(7):1760-1775.
PMID: 33119050
Aims: Atrial fibrillation (AF) is a progressive cardiac arrhythmia that increases the risk of hospitalization and adverse cardiovascular events. There is a clear demand for more inclusive and large-scale approaches...