Thomas Schwarzl
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Explore the profile of Thomas Schwarzl including associated specialties, affiliations and a list of published articles.
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32
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2231
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Recent Articles
1.
Noble M, Chatterjee A, Sekaran T, Schwarzl T, Hentze M
RNA
. 2024 Apr;
30(7):839-853.
PMID: 38609156
Several enzymes of intermediary metabolism have been identified to bind RNA in cells, with potential consequences for the bound RNAs and/or the enzyme. In this study, we investigate the RNA-binding...
2.
Schwarzl T, Sahadevan S, Lang B, Miladi M, Backofen R, Huber W, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):e1.
PMID: 37962298
Enhanced crosslinking and immunoprecipitation (eCLIP) sequencing is a method for transcriptome-wide detection of binding sites of RNA-binding proteins (RBPs). However, identified crosslink sites can deviate from experimentally established functional elements...
3.
Schwarzl T, Keogh A, Shaw G, Krstic A, Clayton E, Higgins D, et al.
Sci Data
. 2023 Nov;
10(1):758.
PMID: 37923731
Articular cartilage has only very limited regenerative capacities in humans. Tissue engineering techniques for cartilage damage repair are limited in the production of hyaline cartilage. Mesenchymal stem/stromal cells (MSCs) are...
4.
Varma E, Burghaus J, Schwarzl T, Sekaran T, Gupta P, Gorska A, et al.
Basic Res Cardiol
. 2023 Jun;
118(1):25.
PMID: 37378715
RNA-protein interactions are central to cardiac function, but how activity of individual RNA-binding protein is regulated through signaling cascades in cardiomyocytes during heart failure development is largely unknown. The mechanistic...
5.
Perez-Perri J, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, et al.
Nat Commun
. 2023 Apr;
14(1):2074.
PMID: 37045843
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical...
6.
Asencio C, Schwarzl T, Sahadevan S, Hentze M
RNA
. 2022 Dec;
29(3):330-345.
PMID: 36574981
Small noncoding RNAs fulfill key functions in cellular and organismal biology, typically working in concert with RNA-binding proteins (RBPs). While proteome-wide methodologies have enormously expanded the repertoire of known RBPs,...
7.
Sahadevan S, Sekaran T, Ashaf N, Fritz M, Hentze M, Huber W, et al.
Bioinformatics
. 2022 Nov;
39(1).
PMID: 36394253
Summary: Transcriptome-wide detection of binding sites of RNA-binding proteins is achieved using Individual-nucleotide crosslinking and immunoprecipitation (iCLIP) and its derivative enhanced CLIP (eCLIP) sequencing methods. Here, we introduce htseq-clip, a...
8.
Huppertz I, Perez-Perri J, Mantas P, Sekaran T, Schwarzl T, Russo F, et al.
Mol Cell
. 2022 Jun;
82(14):2666-2680.e11.
PMID: 35709751
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we report that the catalytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly regulated by RNAs leading...
9.
Sahadevan S, Sekaran T, Schwarzl T
Methods Mol Biol
. 2021 Oct;
2404:189-205.
PMID: 34694610
Individual-nucleotide crosslinking and immunoprecipitation (iCLIP) sequencing and its derivative enhanced CLIP (eCLIP) sequencing are methods for the transcriptome-wide detection of binding sites of RNA-binding proteins (RBPs). This chapter provides a...
10.
Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jurgensen L, et al.
Cell Rep
. 2021 May;
35(6):109100.
PMID: 33979607
RNA-binding proteins (RBPs) control critical aspects of cardiomyocyte function, but the repertoire of active RBPs in cardiomyocytes during the growth response is largely unknown. We define RBPs in healthy and...