Thomas S Kilduff
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Explore the profile of Thomas S Kilduff including associated specialties, affiliations and a list of published articles.
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83
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Recent Articles
41.
Parks G, Warrier D, Dittrich L, Schwartz M, Palmerston J, Neylan T, et al.
Neuropsychopharmacology
. 2015 Aug;
41(4):1144-55.
PMID: 26289145
The dual hypocretin receptor (HcrtR) antagonist almorexant (ALM) may promote sleep through selective disfacilitation of wake-promoting systems, whereas benzodiazepine receptor agonists (BzRAs) such as zolpidem (ZOL) induce sleep through general...
42.
Lindemann L, Porter R, Scharf S, Kuennecke B, Bruns A, von Kienlin M, et al.
J Pharmacol Exp Ther
. 2015 Feb;
353(1):213-33.
PMID: 25665805
Major depressive disorder (MDD) is a serious public health burden and a leading cause of disability. Its pharmacotherapy is currently limited to modulators of monoamine neurotransmitters and second-generation antipsychotics. Recently,...
43.
Vazquez-DeRose J, Schwartz M, Nguyen A, Warrier D, Gulati S, Mathew T, et al.
Brain Struct Funct
. 2014 Nov;
221(2):923-40.
PMID: 25431268
Hypocretin/orexin (HCRT) neurons provide excitatory input to wake-promoting brain regions including the basal forebrain (BF). The dual HCRT receptor antagonist almorexant (ALM) decreases waking and increases sleep. We hypothesized that...
44.
Dittrich L, Morairty S, Warrier D, Kilduff T
Neuropsychopharmacology
. 2014 Aug;
40(3):632-9.
PMID: 25139062
Cortical interneurons, immunoreactive for neuronal nitric oxide synthase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep. NREM sleep 'pressure' is hypothesized to accumulate during...
45.
Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka K, Hasuwa H, et al.
J Neurosci
. 2014 May;
34(20):6896-909.
PMID: 24828644
Melanin-concentrating hormone (MCH) is a neuropeptide produced in neurons sparsely distributed in the lateral hypothalamic area. Recent studies have reported that MCH neurons are active during rapid eye movement (REM)...
46.
Tabuchi S, Tsunematsu T, Black S, Tominaga M, Maruyama M, Takagi K, et al.
J Neurosci
. 2014 May;
34(19):6495-509.
PMID: 24806676
The sleep disorder narcolepsy results from loss of hypothalamic orexin/hypocretin neurons. Although narcolepsy onset is usually postpubertal, current mouse models involve loss of either orexin peptides or orexin neurons from...
47.
Black S, Morairty S, Chen T, Leung A, Wisor J, Yamanaka A, et al.
J Neurosci
. 2014 May;
34(19):6485-94.
PMID: 24806675
γ-Hydroxybutyrate (GHB) is an approved therapeutic for the excessive sleepiness and sudden loss of muscle tone (cataplexy) characteristic of narcolepsy. The mechanism of action for these therapeutic effects is hypothesized...
48.
The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats
Morairty S, Wilk A, Lincoln W, Neylan T, Kilduff T
Front Neurosci
. 2014 Feb;
8:3.
PMID: 24550767
The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM. HcrtR antagonists are hypothesized to induce sleep...
49.
Morairty S, Dittrich L, Pasumarthi R, Valladao D, Heiss J, Gerashchenko D, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(50):20272-7.
PMID: 24191004
Although the neural circuitry underlying homeostatic sleep regulation is little understood, cortical neurons immunoreactive for neuronal nitric oxide synthase (nNOS) and the neurokinin-1 receptor (NK1) have been proposed to be...
50.
Krystal A, Benca R, Kilduff T
J Clin Psychiatry
. 2013 Oct;
74 Suppl 1:3-20.
PMID: 24107804
No abstract available.