Thomas R Gadek
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Explore the profile of Thomas R Gadek including associated specialties, affiliations and a list of published articles.
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12
Citations
139
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Recent Articles
1.
Semba C, Gadek T
Clin Ophthalmol
. 2016 Jun;
10:1083-94.
PMID: 27354762
Dry eye disease (DED) is a multifactorial disorder of the ocular surface characterized by symptoms of discomfort, decreased tear quality, and chronic inflammation that affects an estimated 20 million patients...
2.
Zhong M, Gadek T, Bui M, Shen W, Burnier J, Barr K, et al.
ACS Med Chem Lett
. 2014 Jun;
3(3):203-6.
PMID: 24900456
LFA-1/ICAM-1 interaction is essential in support of inflammatory and specific T-cell regulated immune responses by mediating cell adhesion, leukocyte extravasation, migration, antigen presentation, formation of immunological synapse, and augmentation of...
3.
Sun Y, Zhang R, Gadek T, ONeill C, Pearlman E
J Ocul Pharmacol Ther
. 2012 Dec;
29(4):395-402.
PMID: 23215542
Purpose: Sterile corneal infiltrates can cause pain, blurred vision, and ocular discomfort in silicone hydrogel contact-lens users. The current study investigates the potential for the synthetic lymphocyte functional antigen-1 (LFA-1)...
4.
Semba C, Swearingen D, Smith V, Newman M, ONeill C, Burnier J, et al.
J Ocul Pharmacol Ther
. 2010 Mar;
27(1):99-104.
PMID: 20334535
Purpose: To investigate the safety, tolerability, and pharmacokinetics (PKs) of topical SAR 1118 Ophthalmic Solution in healthy adults. SAR 1118 is an investigational small molecule lymphocyte function-associated antigen-1 (LFA-1; CD11a/CD18;...
5.
Keating S, Clark K, Stefanich L, Arellano F, Edwards C, Bodary S, et al.
Protein Sci
. 2005 Dec;
15(2):290-303.
PMID: 16384997
The lymphocyte function-associated antigen-1 (LFA-1) binding of a unique class of small-molecule antagonists as represented by compound 3 was analyzed in comparison to that of soluble intercellular adhesion molecule-1 (sICAM-1)...
6.
Burdick D, Marsters Jr J, Aliagas-Martin I, Stanley M, Beresini M, Clark K, et al.
Bioorg Med Chem Lett
. 2004 Apr;
14(9):2055-9.
PMID: 15080978
o-Bromobenzoyl l-tryptophan 1 inhibits the association of LFA-1 with ICAM-1 with an IC(50) of 1.7microM. Evaluation of the structure-activity relationship of the benzoyl moiety shows that 2,6-di-substitutions greatly enhance potency...
7.
Ockey D, Gadek T
Bioorg Med Chem Lett
. 2003 Dec;
14(2):389-91.
PMID: 14698165
A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and...
8.
Ockey D, Dotson J, Struble M, Stults J, Bourell J, Clark K, et al.
Bioorg Med Chem
. 2003 Dec;
12(1):37-44.
PMID: 14697768
A novel class of nonpeptide inhibitors of stromelysin (MMP-3) has been discovered with the use of mass spectrometry. The method relies on the development of structure-activity relationships by mass spectrometry...
9.
Gadek T, McDowell R
Drug Discov Today
. 2003 Jun;
8(12):545-50.
PMID: 12821302
A case study of the discovery of small molecule antagonists to the integrins GPIIbIIIa (alphaII(B)beta3), alphavbeta3, LFA-1 (alphaLbeta2), alpha4beta1 and alpha4beta7 is presented from the perspective of a biotechnology research...
10.
Gadek T
Biotechniques
. 2003 Jun;
Suppl:21-4.
PMID: 12813901
The identification of antagonists of protein-protein interactions is a critical challenge to the pharmaceutical industry. The selection of a protein target, which is amenable to antagonism, is the first of...