Thomas P Slavin
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Explore the profile of Thomas P Slavin including associated specialties, affiliations and a list of published articles.
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65
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1617
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Recent Articles
1.
Pal T, Mundt E, Richardson M, Chao E, Pesaran T, Slavin T, et al.
NPJ Precis Oncol
. 2024 Nov;
8(1):247.
PMID: 39488595
Prior studies have suggested the existence of reduced penetrance pathogenic variants (RPPVs) in BRCA1 and BRCA2 (BRCA) which pose challenges for patient counseling and care. Here, we sought to establish...
2.
Mabey B, Hughes E, Kucera M, Simmons T, Hullinger B, Pederson H, et al.
Genet Med
. 2024 Jun;
26(7):101128.
PMID: 38829299
Purpose: We previously described a combined risk score (CRS) that integrates a multiple-ancestry polygenic risk score (MA-PRS) with the Tyrer-Cuzick (TC) model to assess breast cancer (BC) risk. Here, we...
3.
Lenz L, Neff C, Solimeno C, Cogan E, Abramson V, Boughey J, et al.
Breast Cancer Res Treat
. 2023 Aug;
202(1):191-201.
PMID: 37589839
Purpose: A 3-biomarker homologous recombination deficiency (HRD) score is a key component of a currently FDA-approved companion diagnostic assay to identify HRD in patients with ovarian cancer using a threshold...
4.
Kurian A, Abrahamse P, Furgal A, Ward K, Hamilton A, Hodan R, et al.
JAMA
. 2023 Jun;
330(1):43-51.
PMID: 37276540
Importance: Germline genetic testing is recommended by practice guidelines for patients diagnosed with cancer to enable genetically targeted treatment and identify relatives who may benefit from personalized cancer screening and...
5.
Jones M, Timms K, Hatcher S, Cogan E, Comeaux M, Perry M, et al.
Genes Chromosomes Cancer
. 2023 May;
62(10):589-596.
PMID: 37222498
Background: Approximately half of ovarian tumors have defects within the homologous recombination repair pathway. Tumors carrying pathogenic variants (PVs) in BRCA1/BRCA2 are more likely to respond to poly-ADP ribose polymerase...
6.
Daly M, Rosenthal E, Cummings S, Bernhisel R, Kidd J, Hughes E, et al.
Breast Cancer Res Treat
. 2023 Apr;
199(3):617-626.
PMID: 37084156
Purpose: Young age at breast cancer (BC) diagnosis and family history of BC are strongly associated with high prevalence of pathogenic variants (PVs) in BRCA1 and BRCA2 genes. There is...
7.
Hughes E, Wagner S, Pruss D, Bernhisel R, Probst B, Abkevich V, et al.
JCO Precis Oncol
. 2022 Nov;
6:e2200084.
PMID: 36331239
Purpose: Polygenic risk scores (PRSs) for breast cancer (BC) risk stratification have been developed primarily in women of European ancestry. Their application to women of non-European ancestry has lagged because...
8.
Constantinidou A, Marcou Y, Toss M, Simmons T, Bernhisel R, Hughes E, et al.
Clin Cancer Res
. 2022 Aug;
28(20):4435-4443.
PMID: 36043530
Purpose: The EndoPredict prognostic assay is validated to predict distant recurrence and response to chemotherapy primarily in post-menopausal women with estrogen receptor-positive (ER+), HER2- breast cancer. This study evaluated the...
9.
Clonal Hematopoiesis and Mosaicism Revealed by a Multi-Tissue Analysis of Constitutional TP53 Status
Castillo D, Yuan T, Nehoray B, Cervantes A, Tsang K, Yang K, et al.
Cancer Epidemiol Biomarkers Prev
. 2022 Jun;
31(8):1621-1629.
PMID: 35654360
Background: Though germline TP53 pathogenic/likely pathogenic variants (PV) are associated with Li-Fraumeni syndrome, many detected by multigene panels represent aberrant clonal expansion (ACE), most due to clonal hematopoiesis (CH). Discerning...
10.
Nehoray B, Slavin T, Sun C, Hurley K, King E, Tsang K, et al.
J Genet Couns
. 2022 May;
31(5):1164-1172.
PMID: 35617031
Next-generation tumor tissue sequencing techniques may result in the detection of putative germline pathogenic variants (PVs), raising the possibility that germline cancer predisposition could be identified from archival medical tissue...