Thomas O Joos
Overview
Explore the profile of Thomas O Joos including associated specialties, affiliations and a list of published articles.
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94
Citations
1836
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Recent Articles
1.
Zimmermann M, Fandrich M, Jakobi M, Roben B, Wurster I, Lerche S, et al.
J Parkinsons Dis
. 2024 Sep;
14(7):1405-1416.
PMID: 39240648
Background: Prior investigations have elucidated pathophysiological interactions involving blood coagulation and neurodegenerative diseases. These interactions pertain to age-related effects and a mild platelet antiaggregant function of exogenous α-Synuclein. Objective: Our...
2.
Naboulsi W, Planatscher H, Schmidt F, Steinhilber A, Joos T, Adedeji A, et al.
EXCLI J
. 2024 Mar;
23:180-197.
PMID: 38487082
Drug-induced kidney injury (DIKI) is a cause of drug development failure. Dogs represent a common non-rodent animal model in pre-clinical safety studies; however, biomarker assays for detecting nephrotoxicity in dogs...
3.
Lerche S, Zimmermann M, Roeben B, Wurster I, Fries F, Deuschle C, et al.
NPJ Parkinsons Dis
. 2023 Mar;
9(1):38.
PMID: 36906614
Inflammation modifies the incidence and progression of Parkinson's disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies...
4.
Lerche S, Zimmermann M, Wurster I, Roeben B, Fries F, Deuschle C, et al.
Front Neurol
. 2022 Mar;
13:834580.
PMID: 35280273
Background: An involvement of the central-nervous and peripheral, innate and adaptive immune system in the pathogenesis of Parkinson's disease (PD) is nowadays well established. Objectives: We face several open questions...
5.
Kratzer U, Sommersdorf C, Maier S, Wagner T, Templin M, Joos T, et al.
Bioconjug Chem
. 2021 Aug;
32(9):1960-1965.
PMID: 34406760
-Hydroxysuccinimide esters of small molecules are widely used to modify biomolecules such as antibodies or proteins. Primary amine groups preferably react with the ester to form covalent amide bonds. Currently,...
6.
Lichtenstein D, Mentz A, Sprenger H, Schmidt F, Albaum S, Kalinowski J, et al.
Toxicology
. 2021 Aug;
460:152892.
PMID: 34371104
While real-life exposure occurs to complex chemical mixtures, toxicological risk assessment mostly focuses on individual compounds. There is an increasing demand for in vitro tools and strategies for mixture toxicity...
7.
Schmidt F, Lichtenstein D, Planatscher H, Mentz A, Kalinowski J, Steinhilber A, et al.
Toxicology
. 2021 Jun;
458:152839.
PMID: 34153374
Toxicological effects of chemicals are mostly tested individually. However, consumers encounter exposure to complex mixtures, for example multiple pesticide residues, by consuming food such as crops, fruits or vegetables. Currently,...
8.
Fink S, Ruoff F, Stahl A, Becker M, Kaiser P, Traenkle B, et al.
ACS Infect Dis
. 2021 Mar;
7(6):1596-1606.
PMID: 33724771
The presence of antibodies against endemic coronaviruses has been linked to disease severity after SARS-CoV-2 infection. Assays capable of concomitantly detecting antibodies against endemic coronaviridae such as OC43, 229E, NL63,...
9.
Becker M, Strengert M, Junker D, Kaiser P, Kerrinnes T, Traenkle B, et al.
Nat Commun
. 2021 Feb;
12(1):1152.
PMID: 33608538
The humoral immune response to SARS-CoV-2 is a benchmark for immunity and detailed analysis is required to understand the manifestation and progression of COVID-19, monitor seroconversion within the general population,...
10.
Ghosh M, Hartmann H, Jakobi M, Marz L, Bichmann L, Freudenmann L, et al.
Front Bioeng Biotechnol
. 2021 Jan;
8:571294.
PMID: 33392160
Biomaterials play an increasing role in clinical applications and regenerative medicine. A perfectly designed biomaterial should restore the function of damaged tissue without triggering an undesirable immune response, initiate self-regeneration...