Thomas N Sato
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Explore the profile of Thomas N Sato including associated specialties, affiliations and a list of published articles.
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30
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2530
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Recent Articles
1.
Tejima K, Kozawa S, Sato T
PLoS Genet
. 2024 Nov;
20(11):e1011436.
PMID: 39556600
While single-cell RNA-sequencing (scRNA-seq) is a popular method to analyze gene expression and cellular composition at single-cell resolution, it harbors shortcomings: The failure to account for cell-to-cell variations of transcriptome-size...
2.
Kozawa S, Tejima K, Takagi S, Kuroda M, Nogami-Itoh M, Kitamura H, et al.
Sci Rep
. 2023 Dec;
13(1):21981.
PMID: 38081956
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by complex lung pathogenesis affecting approximately three million people worldwide. While the molecular and cellular details of the IPF...
3.
Kozawa S, Yokoyama H, Urayama K, Tejima K, Doi H, Takagi S, et al.
Bioinform Adv
. 2023 May;
3(1):vbad047.
PMID: 37123453
Motivation: Human diseases are characterized by multiple features such as their pathophysiological, molecular and genetic changes. The rapid expansion of such multi-modal disease-omics space provides an opportunity to re-classify diverse...
4.
Kozawa S, Sagawa F, Endo S, De Almeida G, Mitsuishi Y, Sato T
iScience
. 2020 Jan;
23(2):100791.
PMID: 31928967
Approximately 90% of pre-clinically validated drugs fail in clinical trials owing to unanticipated clinical outcomes, costing over several hundred million US dollars per drug. Despite such critical importance, translating pre-clinical...
5.
Kozawa S, Ueda R, Urayama K, Sagawa F, Endo S, Shiizaki K, et al.
iScience
. 2018 Nov;
2:238-268.
PMID: 30428375
Virtually all diseases affect multiple organs. However, our knowledge of the body-wide effects remains limited. Here, we report the body-wide transcriptome landscape across 13-23 organs of mouse models of myocardial...
6.
Duan L, Pan S, Sato T, Fong G
Sci Rep
. 2017 Dec;
7(1):17608.
PMID: 29242645
In mice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery. The retinal vasculature grows towards the...
7.
Takada N, Omae M, Sagawa F, Chi N, Endo S, Kozawa S, et al.
Biol Open
. 2017 Oct;
6(11):1756-1770.
PMID: 28982700
The cardiovascular system facilitates body-wide distribution of oxygen, a vital process for the development and survival of virtually all vertebrates. However, the zebrafish, a vertebrate model organism, appears to form...
8.
9.
Kozawa S, Akanuma T, Sato T, Sato Y, Ikeda K, Sato T
Sci Rep
. 2016 Sep;
6:32962.
PMID: 27597656
Combination of live-imaging and live-manipulation of developing embryos in vivo provides a useful tool to study developmental processes. Identification and selection of target cells for an in vivo live-manipulation are...
10.
Akanuma T, Chen C, Sato T, Merks R, Sato T
Nat Commun
. 2016 Jun;
7:11963.
PMID: 27349214
Cell shape influences function, and the current model suggests that such shape effect is transient. However, cells dynamically change their shapes, thus, the critical question is whether shape information remains...