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Thomas McMahon

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Articles 26
Citations 954
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Recent Articles
1.
Levine D, Reeh R, McMahon T, Mandrup-Poulsen T, Fu Y, Ptacek L
bioRxiv . 2024 Feb; PMID: 38352599
Highlights: High fat diet promotes entrainment to summer but inhibits entrainment to winter.Calorie restriction promotes entrainment to winter but inhibits entrainment to summer.PER2-S662 phosphorylation is required for nutritional regulation of...
2.
Young M, Just J, Lee Y, McMahon T, Gonzalez J, Noh S, et al.
bioRxiv . 2023 Dec; PMID: 38077090
The microbiome is increasingly recognized for its complex relationship with host fitness. Bumblebees are host to a characteristic gut microbiome community that is derived and reinforced through social contact between...
3.
Dong Q, Gentry N, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, et al.
iScience . 2022 May; 25(4):103964. PMID: 35496999
Although numerous studies have demonstrated that poor sleep increases the development of AD, direct evidence elucidating the benefits of good sleep on the AD pathogenesis is lacking. Familial Natural Short...
4.
Gentry N, McMahon T, Yamazaki M, Webb J, Arnold T, Rosi S, et al.
Neurobiol Sleep Circadian Rhythms . 2022 Jan; 12:100073. PMID: 35028489
Sleep deprivation can generate inflammatory responses in the central nervous system. In turn, this inflammation increases sleep drive, leading to a rebound in sleep duration. Microglia, the innate immune cells...
5.
Fay A, Garcia Y, Margeta M, Maharjan S, Jurgensen C, Briceno J, et al.
Ann Neurol . 2020 Jul; 88(4):830-842. PMID: 32715519
Objective: The objective of this study was to identify the genetic cause for progressive peripheral nerve disease in a Venezuelan family. Despite the growing list of genes associated with Charcot-Marie-Tooth...
6.
Shi G, Xing L, Wu D, Bhattacharyya B, Jones C, McMahon T, et al.
Neuron . 2019 Sep; 103(6):1044-1055.e7. PMID: 31473062
Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases...
7.
Kurien P, Hsu P, Leon J, Wu D, McMahon T, Shi G, et al.
Proc Natl Acad Sci U S A . 2019 May; 116(24):12045-12053. PMID: 31138685
Many components of the circadian molecular clock are conserved from flies to mammals; however, the role of mammalian Timeless remains ambiguous. Here, we report a mutation in the human (h)...
8.
Hirano A, Hsu P, Zhang L, Xing L, McMahon T, Yamazaki M, et al.
Proc Natl Acad Sci U S A . 2018 Mar; 115(13):3434-3439. PMID: 29531056
Adequate sleep is essential for physical and mental health. We previously identified a missense mutation in the human gene () leading to the familial natural short sleep behavioral trait. DEC2...
9.
Blasio A, Wang J, Wang D, Varodayan F, Pomrenze M, Miller J, et al.
Biol Psychiatry . 2017 Dec; 84(3):193-201. PMID: 29198469
Background: Despite the high cost and widespread prevalence of alcohol use disorders, treatment options are limited, underscoring the need for new, effective medications. Previous results using protein kinase C epsilon...
10.
Hirano A, Shi G, Jones C, Lipzen A, Pennacchio L, Xu Y, et al.
Elife . 2016 Aug; 5. PMID: 27529127
Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype characterized by very early sleep and wake times. We identified a missense mutation in the human Cryptochrome 2 (CRY2)...