A Rare Mutation of β-Adrenergic Receptor Affects Sleep/Wake Behaviors

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2019 Sep 2

PMID 31473062

Citations 30

Authors

Guangsen Shi

Lijuan Xing

David Wu

Bula J Bhattacharyya

Christopher R Jones

Thomas McMahon

S Y Christin Chong

Jason A Chen

Giovanni Coppola

Daniel Geschwind

Andrew Krystal

Louis J Ptacek

Ying-Hui Fu

Affiliations

Soon will be listed here.

Abstract

Sleep is crucial for our survival, and many diseases are linked to long-term poor sleep quality. Before we can use sleep to enhance our health and performance and alleviate diseases associated with poor sleep, a greater understanding of sleep regulation is necessary. We have identified a mutation in the β-adrenergic receptor gene in humans who require fewer hours of sleep than most. In vitro, this mutation leads to decreased protein stability and dampened signaling in response to agonist treatment. In vivo, the mice carrying the same mutation demonstrated short sleep behavior. We found that this receptor is highly expressed in the dorsal pons and that these ADRB1 neurons are active during rapid eye movement (REM) sleep and wakefulness. Activating these neurons can lead to wakefulness, and the activity of these neurons is affected by the mutation. These results highlight the important role of β-adrenergic receptors in sleep/wake regulation.

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