Thomas Mager
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Explore the profile of Thomas Mager including associated specialties, affiliations and a list of published articles.
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15
Citations
336
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Recent Articles
1.
Huet A, Mager T, Gossler C, Moser T
Annu Rev Neurosci
. 2024 Apr;
47(1):103-121.
PMID: 38594945
The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables speech comprehension in the majority of the million otherwise deaf patients. In hearing by electrical stimulation of...
2.
Aline Schmoll K, Mager T, Tse T, Alameldeen A, Zimmermann W, Zafeiriou M
Stem Cell Res
. 2024 Jan;
75:103317.
PMID: 38295750
Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal connectivity with other excitable cells...
3.
Zerche M, Wrobel C, Kusch K, Moser T, Mager T
Mol Ther Methods Clin Dev
. 2023 Apr;
29:202-212.
PMID: 37081855
Sensory restoration by optogenetic neurostimulation provides a promising future alternative to current electrical stimulation approaches. So far, channelrhodopsins (ChRs) typically contain a C-terminal fluorescent protein (FP) tag for visualization that...
4.
Mager T
Methods Mol Biol
. 2022 Jul;
2501:277-288.
PMID: 35857233
Optogenetics is of key importance for progress in basic neuroscience research and the development of innovative future medical treatments. In particular, the use of microbial rhodopsins enables remote control of...
5.
Weissbecker J, Boumrifak C, Breyer M, Wiessalla T, Shevchenko V, Mager T, et al.
Angew Chem Int Ed Engl
. 2021 Aug;
60(42):23010-23017.
PMID: 34339559
The new class of microbial rhodopsins, called xenorhodopsins (XeRs), extends the versatility of this family by inward H pumps. These pumps are an alternative optogenetic tool to the light-gated ion...
6.
Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet A, et al.
EMBO Mol Med
. 2021 May;
13(6):e13391.
PMID: 33960685
Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants...
7.
Zabelskii D, Alekseev A, Kovalev K, Rankovic V, Balandin T, Soloviov D, et al.
Nat Commun
. 2020 Nov;
11(1):5707.
PMID: 33177509
Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses...
8.
Bratanov D, Kovalev K, Machtens J, Astashkin R, Chizhov I, Soloviov D, et al.
Nat Commun
. 2019 Nov;
10(1):4939.
PMID: 31666521
Recently, two groups of rhodopsin genes were identified in large double-stranded DNA viruses. The structure and function of viral rhodopsins are unknown. We present functional characterization and high-resolution structure of...
9.
Vinayagam D, Mager T, Apelbaum A, Bothe A, Merino F, Hofnagel O, et al.
Elife
. 2018 May;
7.
PMID: 29717981
Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca signaling and have been proposed to act as store-operated channels (SOC). Their malfunction is related...
10.
Mager T, Lopez de la Morena D, Senn V, Schlotte J, D Errico A, Feldbauer K, et al.
Nat Commun
. 2018 May;
9(1):1750.
PMID: 29717130
Optogenetics revolutionizes basic research in neuroscience and cell biology and bears potential for medical applications. We develop mutants leading to a unifying concept for the construction of various channelrhodopsins with...