Thomas M Jeitner
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Explore the profile of Thomas M Jeitner including associated specialties, affiliations and a list of published articles.
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37
Citations
610
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Recent Articles
1.
Azcona J, Wacker A, Lee C, Fung E, Jeitner T, Manzo O, et al.
Mol Imaging Biol
. 2025 Jan;
27(1):109-119.
PMID: 39810069
Purpose: Treatment of pediatric cancers with doxorubicin is a common and predictable cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and intervention are major determinants for the prevention of advanced...
2.
Azcona J, Wacker A, Lee C, Fung E, Jeitner T, Manzo O, et al.
Res Sq
. 2024 Nov;
PMID: 39483906
Purpose: Treatment of pediatric cancers with doxorubicin is a common and predictable cause of cardiomyopathy. Early diagnosis of treatment-induced cardiotoxicity and intervention are major determinants for the prevention of advanced...
3.
Di Bona M, Chen Y, Agustinus A, Mazzagatti A, Duran M, Deyell M, et al.
Science
. 2024 Aug;
385(6712):eadj8691.
PMID: 39208110
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture catalyzes chromosomal rearrangements, epigenetic abnormalities, and inflammation, yet...
4.
Jeitner T, Azcona J, Ables G, Cooke D, Horowitz M, Singh P, et al.
Geroscience
. 2023 May;
46(4):3617-3634.
PMID: 37217633
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of ...
5.
Jeitner T, Kelly J
Anal Biochem
. 2022 Sep;
657:114885.
PMID: 36113550
Mammalian transglutaminase 2 exhibits poor long-term stability in solution. Reconstituting lyophilized transglutaminase 2 in solutions containing dithiothreitol and EDTA alone and together with glycerol stabilizes the activity of this enzyme...
6.
Jeitner T, Babich J, Kelly J
Transl Oncol
. 2022 May;
22:101450.
PMID: 35597190
The validation of prostate specific membrane antigen (PSMA) as a molecular target in metastatic castration-resistant prostate cancer has stimulated the development of multiple classes of theranostic ligands that specifically target...
7.
Azcona J, Tang S, Berry E, Zhang F, Garvey R, Falck J, et al.
J Pharmacol Exp Ther
. 2022 Mar;
381(3):204-216.
PMID: 35306474
Compensatory angiogenesis is an important adaptation for recovery from critical ischemia. We recently identified 20-hydroxyeicosatetraenoic acid (20-HETE) as a novel contributor of ischemia-induced angiogenesis. However, the precise mechanisms by which...
8.
Kelly J, Jeitner T, Waterhouse N, Qu W, Linstad E, Samani B, et al.
Molecules
. 2022 Mar;
27(5).
PMID: 35268652
Cancer cells require lipids to fulfill energetic, proliferative, and signaling requirements. Even though these cells can take up exogenous fatty acids, the majority exhibit a dependency on de novo fatty...
9.
Kelly J, Jeitner T, Ponnala S, Williams Jr C, Nikolopoulou A, DiMagno S, et al.
Mol Imaging Biol
. 2021 Mar;
23(5):686-696.
PMID: 33721173
Purpose: Fibroblast activation protein-α (FAPα) is uniquely expressed in activated fibroblasts, including cancer-associated fibroblasts that populate tumor stroma and contribute to proliferation and immunosuppression. Radiolabeled FAPα inhibitors enable imaging of...
10.
Jeitner T, Pinto J, Cooper A
Biosci Rep
. 2018 Jul;
38(5).
PMID: 30054429
Cystamine is commonly used as a transglutaminase inhibitor. This disulphide undergoes reduction to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity could be due to...