John T Pinto
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Explore the profile of John T Pinto including associated specialties, affiliations and a list of published articles.
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73
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2698
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Recent Articles
1.
Cooper A, Dorai T, Pinto J, Denton T
Biology (Basel)
. 2023 Aug;
12(8).
PMID: 37627015
Many cancers utilize l-glutamine as a major energy source. Often cited in the literature as "l-glutamine addiction", this well-characterized pathway involves hydrolysis of l-glutamine by a glutaminase to l-glutamate, followed...
2.
Cooper A, Dorai T, Pinto J, Denton T
Front Med (Lausanne)
. 2022 Nov;
13:1035335.
PMID: 36404951
No abstract available.
3.
Kumar A, Vaish M, Karuppagounder S, Gazaryan I, Cave J, Starkov A, et al.
Elife
. 2021 Oct;
10.
PMID: 34596045
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen...
4.
Dorai T, Pinto J, Denton T, Krasnikov B, Cooper A
Anal Biochem
. 2020 Dec;
644:114083.
PMID: 33352190
In rapidly dividing cells, including many cancer cells, l-glutamine is a major energy source. Utilization of glutamine is usually depicted as: l-glutamine → l-glutamate (catalyzed by glutaminase isozymes; GLS1 and...
5.
Cooper A, Dorai T, Pinto J, Denton T
Anal Biochem
. 2020 Dec;
644:114084.
PMID: 33347861
The asparaginase II pathway consists of an asparagine transaminase [l-asparagine + α-keto acid ⇆ α-ketosuccinamate + l-amino acid] coupled to ω-amidase [α-ketosuccinamate + HO → oxaloacetate + NH]. The net...
6.
Dorai T, Dorai B, Pinto J, Grasso M, Cooper A
Biomolecules
. 2019 Dec;
10(1).
PMID: 31861280
Many tumors readily convert l-glutamine to α-ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tissues...
7.
Karuppagounder S, Alin L, Chen Y, Brand D, Bourassa M, Dietrich K, et al.
Ann Neurol
. 2018 Oct;
84(6):854-872.
PMID: 30294906
Objectives: N-acetylcysteine (NAC) is a clinically approved thiol-containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an "antioxidant," poor understanding of its...
8.
Jeitner T, Pinto J, Cooper A
Biosci Rep
. 2018 Jul;
38(5).
PMID: 30054429
Cystamine is commonly used as a transglutaminase inhibitor. This disulphide undergoes reduction to the aminothiol compound, cysteamine. Thus, the mechanism by which cystamine inhibits transglutaminase activity could be due to...
9.
Nichenametla S, Mattocks D, Malloy V, Pinto J
Ann N Y Acad Sci
. 2018 Jan;
1418(1):80-94.
PMID: 29377163
The mechanisms underlying life span extension by sulfur amino acid restriction (SAAR) are unclear. Cysteine and methionine are essential for the biosynthesis of proteins and glutathione (GSH), a major redox...
10.
Doonan B, Schaafsma E, Pinto J, Wu J, Hsieh T
In Vitro Cell Dev Biol Anim
. 2017 Jun;
53(7):575-578.
PMID: 28646291
Colorectal cancer (CRC) is a major cause of cancer-associated deaths worldwide. Recently, oral administration of resveratrol (trans-3,5,4'-trihydroxystilbene) has been reported to significantly reduce tumor proliferation in colorectal cancer patients, however,...