Thomas Langmann
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Explore the profile of Thomas Langmann including associated specialties, affiliations and a list of published articles.
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155
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5705
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Recent Articles
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Khan A, Wolf A, Langmann T
Biochem Biophys Res Commun
. 2021 Sep;
579:15-21.
PMID: 34583190
Retinal degeneration is a leading cause of visual impairment and blindness worldwide. Microglia reactivity is a hallmark of neurodegenerative diseases and a driving force for retinal cell death and disease...
13.
Chan Y, Dick A, Hall S, Langmann T, Scribner C, Mansfield B
Transl Vis Sci Technol
. 2021 May;
10(4):3.
PMID: 34003982
Subclinical or clinical inflammation often arises during ocular gene therapy with viral vectors. Understanding the biological bases and impacts on efficacy are important for clinical management and the improvement of...
14.
Uemura A, Fruttiger M, DAmore P, De Falco S, Joussen A, Sennlaub F, et al.
Prog Retin Eye Res
. 2021 Feb;
84:100954.
PMID: 33640465
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A, -B, -C, -D, and placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 and 2 (VEGFR1/2), whereas...
15.
Diaz-Lezama N, Wolf A, Koch S, Pfaller A, Biber J, Guillonneau X, et al.
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33503976
Müller cells, the major retinal macroglia, are key to maintaining vascular integrity as well as retinal fluid and ion homeostasis. Although platelet derived growth factor (PDGF) receptor expression in Müller...
16.
Behnke V, Langmann T
Biochem Biophys Rep
. 2020 Dec;
24:100866.
PMID: 33299932
Chronic activation of microglia is associated with retinal degeneration, which makes them a potential therapeutic target for retinal degenerative diseases including age-related macular degeneration (AMD). Interferon-beta (IFN-β) is a potent...
17.
Kinuthia U, Wolf A, Langmann T
Front Immunol
. 2020 Nov;
11:564077.
PMID: 33240260
Diabetic retinopathy is a vision-threatening disease affecting neurons and microvasculature of the retina. The development of this disease is associated with the action of inflammatory factors that are connected to...
18.
Khan A, Langmann T
J Neuroinflammation
. 2020 Nov;
17(1):327.
PMID: 33143743
Background: Retinal degenerative diseases significantly contribute to visual impairment and blindness. Microglia reactivity is a hallmark of neurodegenerative diseases including retinal cell death and immunomodulation emerges as a therapeutic option....
19.
Strunz T, Kiel C, Grassmann F, Ratnapriya R, Kwicklis M, Karlstetter M, et al.
PLoS Genet
. 2020 Sep;
16(9):e1008934.
PMID: 32870927
Significant association signals from genome-wide association studies (GWAS) point to genomic regions of interest. However, for most loci the causative genetic variant remains undefined. Determining expression quantitative trait loci (eQTL)...
20.
Wolf A, Herb M, Schramm M, Langmann T
Nat Commun
. 2020 Jun;
11(1):2709.
PMID: 32483169
Aberrant immune responses including reactive phagocytes are implicated in the etiology of age-related macular degeneration (AMD), a major cause of blindness in the elderly. The translocator protein (18 kDa) (TSPO)...