Thomas Emrich
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Explore the profile of Thomas Emrich including associated specialties, affiliations and a list of published articles.
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25
Citations
676
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Recent Articles
1.
Grathwohl S, Quansah E, Maroof N, Steiner J, Spycher L, Benmansour F, et al.
Free Neuropathol
. 2023 Jun;
2.
PMID: 37284635
: In some people with Parkinson's disease (PD), α-synuclein (αSyn) accumulation may begin in the enteric nervous system (ENS) decades before development of brain pathology and disease diagnosis. : To...
2.
Lauren A, Braun M, Cazzin C, Colleti K, Cox C, Dietz L, et al.
Bioanalysis
. 2022 Sep;
14(16):1085-1093.
PMID: 36125042
In this manuscript, the European Bioanalysis Forum reports back on their discussions on practical and scientific considerations related to bioanalytical applications of quantitative polymerase chain reaction. This publication follows an...
3.
Pohler A, Emrich T, Jordan G, Schafer M, Stubenrauch K, Staack R, et al.
Bioanalysis
. 2022 Sep;
14(13):923-933.
PMID: 36066084
Assessment of pre-existing anti-drug antibody (preADA) reactivity at early drug development stages can be beneficial for candidate selection. We investigated the applicability of a generic immune-complex anti-drug antibody (ADA) assay...
4.
Grevys A, Frick R, Mester S, Flem-Karlsen K, Nilsen J, Foss S, et al.
iScience
. 2022 Feb;
25(2):103746.
PMID: 35118359
Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable pharmacokinetics, it is...
5.
Lauren A, Braun M, Byrne P, Cazzin C, Colletti K, Cox C, et al.
Bioanalysis
. 2021 Oct;
13(23):1723-1729.
PMID: 34708666
Polymerase chain reaction (PCR) is widely used in various fields of laboratory testing, ranging from forensic, molecular biology, medical and diagnostic applications to a wide array of basic research purposes....
6.
Schmitt C, Emrich T, Chebon S, Fernandez E, Petry C, Yoneyama K, et al.
Haemophilia
. 2021 Sep;
27(6):984-992.
PMID: 34480814
Introduction: Emicizumab is a humanised, bispecific monoclonal antibody mimicking the cofactor function of activated factor (F)VIII. It is indicated for routine prophylaxis of bleeding episodes in persons with haemophilia A...
7.
Emrich T, Stracke J, Guo X, Damhjell K, Moelleken J, Vogel R, et al.
Bioanalysis
. 2021 Apr;
13(10):829-840.
PMID: 33890493
Stabilization of critical reagents by freeze-drying would facilitate storage and transportation at ambient temperatures, and simultaneously enable constant reagent performance for long-term bioanalytical support throughout drug development. Freeze-drying as a...
8.
Sum E, Rapp M, Frobel P, Le Clech M, Durr H, Giusti A, et al.
Clin Cancer Res
. 2021 Mar;
27(14):4036-4053.
PMID: 33771854
Purpose: CD40 agonists hold great promise for cancer immunotherapy (CIT) as they enhance dendritic cell (DC) activation and concomitant tumor-specific T-cell priming. However, the broad expression of CD40 accounts for...
9.
Piccoli S, Mehta D, Vitaliti A, Allinson J, Amur S, Eck S, et al.
Bioanalysis
. 2019 Dec;
11(24):2207-2244.
PMID: 31820675
The 2019 13 Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA, USA on April 1-5, 2019 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical...
10.
Kraft T, Richter W, Emrich T, Knaupp A, Schuster M, Wolfert A, et al.
MAbs
. 2019 Nov;
12(1):1683432.
PMID: 31769731
The pharmacokinetic (PK) properties of therapeutic antibodies directly affect efficacy, dose and dose intervals, application route and tissue penetration. In indications where health-care providers and patients can choose between several...