Thomas E Willnow
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Explore the profile of Thomas E Willnow including associated specialties, affiliations and a list of published articles.
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120
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5630
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Recent Articles
1.
Ovesen P, Juul-Madsen K, Telugu N, Schmidt V, Frahm S, Radbruch H, et al.
Glia
. 2024 Dec;
73(4):857-872.
PMID: 39688327
Sorting protein-related receptor containing class A repeats (SORLA) is an intracellular trafficking receptor encoded by the Alzheimer's disease (AD) gene SORL1 (sortilin-related receptor 1). Recent findings argue that altered expression...
2.
Bolduan F, Wetzel A, Giesecke Y, Eichhorn I, Alenina N, Bader M, et al.
Front Endocrinol (Lausanne)
. 2024 May;
15:1331231.
PMID: 38694940
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead...
3.
Kaminska P, Ovesen P, Jakiel M, Obrebski T, Schmidt V, Draminski M, et al.
EMBO Rep
. 2024 Mar;
25(5):2278-2305.
PMID: 38499808
SorLA, encoded by the gene SORL1, is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins...
4.
Juul-Madsen K, Parbo P, Ismail R, Ovesen P, Schmidt V, Madsen L, et al.
Nat Commun
. 2024 Feb;
15(1):1224.
PMID: 38336934
The peripheral immune system is important in neurodegenerative diseases, both in protecting and inflaming the brain, but the underlying mechanisms remain elusive. Alzheimer's Disease is commonly preceded by a prodromal...
5.
Kalnytska O, Qvist P, Kunz S, Conrad T, Willnow T, Schmidt V
iScience
. 2024 Jan;
27(1):108725.
PMID: 38226160
Sorting receptor SORCS2 is a stress-response factor protecting neurons from acute insults, such as during epilepsy. SORCS2 is also expressed in the pancreas, yet its action in this tissue remains...
6.
Febbraro F, Andersen H, Kitt M, Willnow T
Front Cell Dev Biol
. 2023 Oct;
11:1229584.
PMID: 37842085
Vacuolar protein sorting 10 protein (VPS10P) domain receptors are a unique class of intracellular sorting receptors that emerge as major risk factors associated with psychiatric and neurodegenerative diseases, including bipolar...
7.
Garcia J, Krieger K, Loitz C, Perez L, Richards Z, Helou Y, et al.
Cancer Res Commun
. 2023 Mar;
3(3):371-382.
PMID: 36875158
Significance: These findings link vitamin D deficiency and the megalin protein to increased levels of prostate androgens, which may underpin the disparity in lethal prostate cancer in African America men.
8.
Sandmann C, Schulz J, Ruiz-Orera J, Kirchner M, Ziehm M, Adami E, et al.
Mol Cell
. 2023 Feb;
83(6):994-1011.e18.
PMID: 36806354
All species continuously evolve short open reading frames (sORFs) that can be templated for protein synthesis and may provide raw materials for evolutionary adaptation. We analyzed the evolutionary origins of...
9.
Bunatyan L, Margineanu A, Boutin C, Montcouquiol M, Bachmann S, Ilso Christensen E, et al.
Cell Tissue Res
. 2023 Feb;
392(2):535-551.
PMID: 36764939
Motile cilia are protruding organelles on specialized epithelia that beat in a synchronous fashion to propel extracellular fluids. Coordination and orientation of cilia beating on individual cells and across tissues...
10.
Shih A, Chen Y, Speckmann T, Sondergaard E, Schurmann A, Verchere C, et al.
Mol Metab
. 2022 Sep;
65:101585.
PMID: 36055578
Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic...