Regulation of Prostate Androgens by Megalin and 25-hydroxyvitamin D Status: Mechanism for High Prostate Androgens in African American Men

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 6

PMID 36875158

Authors

Jason Garcia

Kirsten D Krieger

Candice Loitz

Lillian M Perez

Zachary A Richards

Yves Helou

Steve Kregel

Sasha Celada

Clementina A Mesaros

Maarten Bosland

Peter H Gann

Thomas E Willnow

Donald Vander Griend

Rick Kittles

Gail S Prins

Trevor Penning

Larisa Nonn

Affiliations

Soon will be listed here.

Abstract

Significance: These findings link vitamin D deficiency and the megalin protein to increased levels of prostate androgens, which may underpin the disparity in lethal prostate cancer in African America men.

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