Thomas E DeCoursey
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Explore the profile of Thomas E DeCoursey including associated specialties, affiliations and a list of published articles.
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72
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2459
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Recent Articles
1.
Jardin C, Derst C, Franzen A, Mahorivska I, DeCoursey T, Musset B, et al.
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001460
Somatic mutations are common in cancer, with only a few driving the progression of the disease, while most are silent passengers. Some mutations may hinder or even reverse cancer progression....
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Shen M, Huang Y, Cai Z, Cherny V, DeCoursey T, Shen J
Biophys J
. 2024 Jul;
123(24):4211-4220.
PMID: 39054673
The molecular mechanisms governing the human voltage-gated proton channel hH1 remain elusive. Here, we used membrane-enabled hybrid-solvent continuous constant pH molecular dynamics (CpHMD) simulations with pH replica exchange to further...
4.
Ayuyan A, Cherny V, Chaves G, Musset B, Cohen F, DeCoursey T
Biophys J
. 2024 Mar;
123(24):4180-4190.
PMID: 38444158
Many membrane proteins are modulated by cholesterol. Here we report profound effects of cholesterol depletion and restoration on the human voltage-gated proton channel, hH1, in excised patches but negligible effects...
5.
DeCoursey T
Annu Rev Physiol
. 2023 Nov;
86:357-377.
PMID: 37931166
A handful of biological proton-selective ion channels exist. Some open at positive or negative membrane potentials, others open at low or high pH, and some are light activated. This review...
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Chaves G, Ayuyan A, Cherny V, Morgan D, Franzen A, Fieber L, et al.
FEBS J
. 2022 Sep;
290(4):1008-1026.
PMID: 36062330
Voltage-gated ion channels, whose first identified function was to generate action potentials, are divided into subfamilies with numerous members. The family of voltage-gated proton channels (H ) is tiny. To...
8.
Ma J, Gao X, Li Y, DeCoursey T, Shull G, Wang H
J Physiol
. 2022 Mar;
600(9):2089-2103.
PMID: 35244217
Regulation of intracellular pH (pH ) in cardiomyocytes is crucial for cardiac function; however, currently known mechanisms for direct or indirect extrusion of acid from cardiomyocytes seem insufficient for energetically...
9.
Sokolov V, Cherny V, Ayuyan A, DeCoursey T
Biochim Biophys Acta Bioenerg
. 2021 Aug;
1862(11):148480.
PMID: 34363792
Voltage-gated proton channels (H1) resemble the voltage-sensing domain of other voltage-gated ion channels, but differ in containing the conduction pathway. Essential to the functions of H1 channels in many cells...
10.
Cherny V, Musset B, Morgan D, Thomas S, Smith S, DeCoursey T
J Gen Physiol
. 2020 Sep;
152(10).
PMID: 32902579
The voltage-gated proton channel (HV1) is a voltage sensor that also conducts protons. The singular ability of protons to penetrate proteins complicates distinguishing closed and open channels. When we replaced...