Deri Morgan
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Explore the profile of Deri Morgan including associated specialties, affiliations and a list of published articles.
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37
Citations
1356
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Recent Articles
1.
Morgan D, Berggren K, Millington G, Smith H, Spiess C, Hixon M, et al.
World J Oncol
. 2024 Dec;
15(6):871-881.
PMID: 39697425
Background: Bladder cancer patients unable to receive cystectomy or who choose to pursue organ-sparing approach are managed with definitive (chemo)radiotherapy. However, this standard of care has not evolved in decades...
2.
Okwuone D, Morgan D, Gan G
Explor Target Antitumor Ther
. 2024 Mar;
5(1):108-119.
PMID: 38468824
Head and neck cancer (HNC) is a challenging disease that lacks effective treatment, particularly in the cases that spread locoregionally and metastasize distantly, dramatically reducing patient survival rates. Expanding the...
3.
Chaves G, Ayuyan A, Cherny V, Morgan D, Franzen A, Fieber L, et al.
FEBS J
. 2022 Sep;
290(4):1008-1026.
PMID: 36062330
Voltage-gated ion channels, whose first identified function was to generate action potentials, are divided into subfamilies with numerous members. The family of voltage-gated proton channels (H ) is tiny. To...
4.
Morgan D, Berggren K, Spiess C, Smith H, Tejwani A, Weir S, et al.
Mol Carcinog
. 2021 Sep;
61(2):173-199.
PMID: 34559922
Cancer and the immune system share an intimate relationship. Chronic inflammation increases the risk of cancer occurrence and can also drive inflammatory mediators into the tumor microenvironment enhancing tumor growth...
5.
Cherny V, Musset B, Morgan D, Thomas S, Smith S, DeCoursey T
J Gen Physiol
. 2020 Sep;
152(10).
PMID: 32902579
The voltage-gated proton channel (HV1) is a voltage sensor that also conducts protons. The singular ability of protons to penetrate proteins complicates distinguishing closed and open channels. When we replaced...
6.
DiScala M, Najor M, Yung T, Morgan D, Abukhdeir A, Cobleigh M
PLoS One
. 2020 Jun;
15(6):e0234146.
PMID: 32525891
Approximately 20% of breast cancers are HER2-positive. Trastuzumab has improved patient outcomes significantly for these cancers. However, acquired resistance remains a major hurdle in the clinical management of these patients....
7.
Bare D, Cherny V, DeCoursey T, Abukhdeir A, Morgan D
PLoS One
. 2020 May;
15(5):e0227522.
PMID: 32374759
Expression of the voltage gated proton channel (Hv1) as identified by immunocytochemistry has been reported previously in breast cancer tissue. Increased expression of HV1 was correlated with poor prognosis and...
8.
Banh R, Cherny V, Morgan D, Musset B, Thomas S, Kulleperuma K, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(38):18951-18961.
PMID: 31462498
The hydrophobic gasket (HG), a ring of hydrophobic amino acids in the voltage-sensing domain of most voltage-gated ion channels, forms a constriction between internal and external aqueous vestibules. Cationic Arg...
9.
Thomas S, Cherny V, Morgan D, Artinian L, Rehder V, Smith S, et al.
J Gen Physiol
. 2018 May;
150(6):835-850.
PMID: 29743301
Voltage-gated proton channels, H1, were first reported in snail neurons. These H channels open very rapidly, two to three orders of magnitude faster than mammalian H1. Here we identify an...
10.
Cherny V, Morgan D, Thomas S, Smith S, DeCoursey T
J Gen Physiol
. 2018 May;
150(6):851-862.
PMID: 29743300
We recently identified a voltage-gated proton channel gene in the snail , HtH1, and determined its electrophysiological properties. Consistent with early studies of proton currents in snail neurons, HtH1 opens...