Thomas D M Hill
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Explore the profile of Thomas D M Hill including associated specialties, affiliations and a list of published articles.
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8
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153
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Recent Articles
1.
Mamad O, Heiland M, Lindner A, Hill T, Ronroy R, Rentrup K, et al.
Front Pharmacol
. 2024 Jan;
14:1308478.
PMID: 38259288
There remains a need for new drug targets for treatment-resistant temporal lobe epilepsy. The ATP-gated P2X7 receptor coordinates neuroinflammatory responses to tissue injury. Previous studies in mice reported that the...
2.
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Brindley E, Heiland M, Mooney C, Diviney M, Mamad O, Hill T, et al.
Front Mol Neurosci
. 2023 Oct;
16:1230942.
PMID: 37808470
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are...
3.
Heiland M, Connolly N, Mamad O, Nguyen N, Kesavan J, Langa E, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2216658120.
PMID: 37463203
There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium channel blockers are effective for seizure control in common forms of epilepsy, but loss of sodium channel function...
4.
Morris G, Heiland M, Lamottke K, Guan H, Hill T, Zhou Y, et al.
Front Neurol
. 2022 Jan;
12:791608.
PMID: 35069421
Drug-resistant epilepsy remains a significant clinical and societal burden, with one third of people with epilepsy continuing to experience seizures despite the availability of around 30 anti-seizure drugs (ASDs). Further,...
5.
Brennan G, Bauer S, Engel T, Jimenez-Mateos E, Del Gallo F, Hill T, et al.
Neurobiol Dis
. 2020 Aug;
144:105048.
PMID: 32800995
Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is therefore an unmet clinical need for a...
6.
Batool A, Hill T, Nguyen N, Langa E, Diviney M, Mooney C, et al.
Front Neurosci
. 2020 Feb;
13:1404.
PMID: 32009885
Repetitive or prolonged seizures (status epilepticus) can damage neurons within the hippocampus, trigger gliosis, and generate an enduring state of hyperexcitability. Recent studies have suggested that microvesicles including exosomes are...
7.
Brindley E, Hill T, Henshall D
Epilepsy Behav
. 2019 Jun;
101(Pt B):106272.
PMID: 31171435
Microribonucleic acids (miRNAs) are short noncoding ribonucleic acids (RNAs) that have been proposed as potential biomarkers for epilepsy, acute seizures, and status epilepticus. Various properties support their potential in this...
8.
Jones N, Glyn S, Akiyama S, Hill T, Hill A, Weston S, et al.
Seizure
. 2012 Apr;
21(5):344-52.
PMID: 22520455
Cannabis sativa has been associated with contradictory effects upon seizure states despite its medicinal use by numerous people with epilepsy. We have recently shown that the phytocannabinoid cannabidiol (CBD) reduces...