Thomas Arendt
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Explore the profile of Thomas Arendt including associated specialties, affiliations and a list of published articles.
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167
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5054
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Recent Articles
1.
Bullmann T, Kaas T, Ritzau-Jost A, Wohner A, Kirmann T, Rizalar F, et al.
J Neurosci
. 2024 May;
44(24).
PMID: 38724283
Understanding the function of the human brain requires determining basic properties of synaptic transmission in human neurons. One of the most fundamental parameters controlling neurotransmitter release is the presynaptic action...
2.
Turan Z, Richter V, Bochmann J, Parvizi P, Yapar E, Isildak U, et al.
Acta Neuropathol Commun
. 2022 Dec;
10(1):175.
PMID: 36451207
The possible role of somatic copy number variations (CNVs) in Alzheimer's disease (AD) aetiology has been controversial. Although cytogenetic studies suggested increased CNV loads in AD brains, a recent single-cell...
3.
Schmidt S, Holzer M, Arendt T, Sonntag M, Morawski M
Biomolecules
. 2022 Apr;
12(4).
PMID: 35454094
Tau mutations promote the formation of tau oligomers and filaments, which are neuropathological signs of several tau-associated dementias. Types of neurons in the CNS are spared of tau pathology and...
4.
Conze C, Rierola M, Trushina N, Peters M, Janning D, Holzer M, et al.
Mol Psychiatry
. 2022 Apr;
27(7):3010-3023.
PMID: 35393558
The microtubule-associated protein tau plays a central role in tauopathies such as Alzheimer's disease (AD). The exact molecular mechanisms underlying tau toxicity are unclear, but aging is irrefutably the biggest...
5.
Reinert A, Reinert T, Arendt T, Morawski M
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163558
A subpopulation of neurons is less vulnerable against iron-induced oxidative stress and neurodegeneration. A key feature of these neurons is a special extracellular matrix composition that forms a perineuronal net...
6.
Rusch H, Brammerloh M, Stieler J, Sonntag M, Mohammadi S, Weiskopf N, et al.
Neuroimage
. 2021 Dec;
247:118832.
PMID: 34929383
The accessibility of new wide-scale multimodal imaging techniques led to numerous clearing techniques emerging over the last decade. However, clearing mesoscopic-sized blocks of aged human brain tissue remains an extremely...
7.
Jorge N, Ueberham U, Knobloch M, Stadler P, Fallmann J, Arendt T
Sci Rep
. 2021 Nov;
11(1):22582.
PMID: 34782714
No abstract available.
8.
Jorge N, Ueberham U, Knobloch M, Stadler P, Fallmann J, Arendt T
Sci Rep
. 2021 Oct;
11(1):20200.
PMID: 34642398
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with typical neuropathological hallmarks, such as neuritic plaques and neurofibrillary tangles, preferentially found at layers III and V. The distribution of both...
9.
Brammerloh M, Morawski M, Friedrich I, Reinert T, Lange C, Pelicon P, et al.
Neuroimage
. 2021 Jun;
239:118255.
PMID: 34119638
In Parkinson's disease, the depletion of iron-rich dopaminergic neurons in nigrosome 1 of the substantia nigra precedes motor symptoms by two decades. Methods capable of monitoring this neuronal depletion, at...
10.
Portillo M, Eremenko E, Kaluski S, Garcia-Venzor A, Onn L, Stein D, et al.
Cell Rep
. 2021 Apr;
35(4):109035.
PMID: 33910019
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegeneration. Here, we show that Tau hyper-acetylation at...