Gudrun Seeger
Overview
Explore the profile of Gudrun Seeger including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
300
Followers
0
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Recent Articles
1.
Munzker J, Haase N, Till A, Sucher R, Haange S, Nemetschke L, et al.
Microbiome
. 2022 Jun;
10(1):96.
PMID: 35739571
Background: Bariatric surgery remains the most effective therapy for adiposity reduction and remission of type 2 diabetes. Although different bariatric procedures associate with pronounced shifts in the gut microbiota, their...
2.
Sonntag M, Blosa M, Schmidt S, Reimann K, Blum K, Eckrich T, et al.
BMC Biol
. 2018 Sep;
16(1):99.
PMID: 30253762
Background: Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are...
3.
Bullmann T, Seeger G, Stieler J, Hanics J, Reimann K, Kretzschmann T, et al.
Hippocampus
. 2015 Sep;
26(3):301-18.
PMID: 26332578
The microtubule-associated protein tau, in its hyperphosphorylated form, is the major component of paired helical filaments and other aggregates in neurodegenerative disorders commonly referred to as "tauopathies". Recent evidence, however,...
4.
Hartig W, Michalski D, Seeger G, Voigt C, Donat C, Dulin J, et al.
Brain Res
. 2012 Dec;
1498:69-84.
PMID: 23268351
The inflammatory response following traumatic brain injury (TBI) contributes to neuronal death with poor outcome. Although anti-inflammatory strategies were beneficial in the experimental TBI, clinical translations mostly failed, probably caused...
5.
Morawski M, Bruckner G, Jager C, Seeger G, Matthews R, Arendt T
Brain Pathol
. 2011 Dec;
22(4):547-61.
PMID: 22126211
Brain extracellular matrix (ECM) is organized in specific patterns assumed to mirror local features of neuronal activity and synaptic plasticity. Aggrecan-based perineuronal nets (PNs) and brevican-based perisynaptic axonal coats (ACs)...
6.
Seeger G, Gartner U, Ueberham U, Rohn S, Arendt T
Neurobiol Dis
. 2009 May;
35(2):258-63.
PMID: 19450683
Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with extracellular accumulation of Abeta peptide that derives from the amyloid precursor protein (APP). While amyloidogenic processing of APP has received...
7.
Morawski M, Pavlica S, Seeger G, Grosche J, Kouznetsova E, Schliebs R, et al.
Neurobiol Aging
. 2008 Oct;
31(7):1254-6.
PMID: 18829133
Changes in the molecular organization of the extracellular matrix are key factors in neuropathology. We investigated aggrecan-based perineuronal nets (PNs) in relation to neurodegeneration and activation of glial cells in...
8.
Alpar A, Ueberham U, Seeger G, Arendt T, Gartner U
Neuroreport
. 2007 Jul;
18(12):1247-50.
PMID: 17632276
Alzheimer's disease is characterized by severe neuronal disintegration supposed to be partly associated with amyloid pathology. Recently, we described morphological alterations of pyramidal cell structure in transgenic mice expressing wild-type...
9.
Alpar A, Ueberham U, Bruckner M, Seeger G, Arendt T, Gartner U
Brain Res
. 2006 Jun;
1099(1):189-98.
PMID: 16781686
The extracellular deposition of amyloid-beta peptide (Abeta) in brain parenchyma is one of the characteristic features of Alzheimer's disease and is suggested to induce reactive and degenerative changes in neuronal...
10.
Ueberham U, Ueberham E, Bruckner M, Seeger G, Gartner U, Gruschka H, et al.
Eur J Neurosci
. 2005 Jul;
22(1):50-64.
PMID: 16029195
Various chronic neurological diseases are associated with increased expression of transforming growth factor-beta1 (TGF-beta1) in the brain. TGF-beta1 has both neuroprotective and neurodegenerative functions, depending on conditions such as duration...