Thomas A Sasani
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Explore the profile of Thomas A Sasani including associated specialties, affiliations and a list of published articles.
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16
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1117
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Recent Articles
1.
Porubsky D, Dashnow H, Sasani T, Logsdon G, Hallast P, Noyes M, et al.
bioRxiv
. 2024 Aug;
PMID: 39149261
Using five complementary short- and long-read sequencing technologies, we phased and assembled >95% of each diploid human genome in a four-generation, 28-member family (CEPH 1463) allowing us to systematically assess...
2.
Xu K, Zhang Y, Baldwin-Brown J, Sasani T, Phadnis N, Miller M, et al.
bioRxiv
. 2024 Jun;
PMID: 38895449
Genomic approaches have provided detailed insight into chromosome architecture. However, commonly deployed techniques do not preserve connectivity-based information, leaving large-scale genome organization poorly characterized. Here, we developed CheC-PLS: a proximity-labeling...
3.
Sasani T, Quinlan A, Harris K
Elife
. 2024 Feb;
12.
PMID: 38381482
Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair, have largely eluded detection in mammals. DNA replication and repair...
4.
Sasani T, Quinlan A, Harris K
bioRxiv
. 2023 May;
PMID: 37162999
Maintaining germline genome integrity is essential and enormously complex. Although many proteins are involved in DNA replication, proofreading, and repair [1], have largely eluded detection in mammals. DNA replication and...
5.
Fixsen S, Cone K, Goldstein S, Sasani T, Quinlan A, Rothenburg S, et al.
Elife
. 2022 Sep;
11.
PMID: 36069526
Horizontal gene transfer (HGT) provides a major source of genetic variation. Many viruses, including poxviruses, encode genes with crucial functions directly gained by gene transfer from hosts. The mechanism of...
6.
Sasani T, Ashbrook D, Beichman A, Lu L, Palmer A, Williams R, et al.
Nature
. 2022 May;
605(7910):497-502.
PMID: 35545679
Although germline mutation rates and spectra can vary within and between species, common genetic modifiers of the mutation rate have not been identified in nature. Here we searched for loci...
7.
Belyeu J, Sasani T, Pedersen B, Quinlan A
Bioinformatics
. 2021 Jun;
37(24):4860-4861.
PMID: 34146087
Summary: Unfazed is a command-line tool to determine the parental gamete of origin for de novo mutations from paired-end Illumina DNA sequencing reads. Unfazed uses variant information for a sequenced...
8.
Wallace A, Sasani T, Swanier J, Gates B, Greenland J, Pedersen B, et al.
PLoS One
. 2021 Apr;
16(4):e0241253.
PMID: 33830997
A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as...
9.
Cawthon R, Meeks H, Sasani T, Smith K, Kerber R, OBrien E, et al.
Sci Rep
. 2020 Jun;
10(1):10001.
PMID: 32561805
Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining...
10.
Sasani T, Pedersen B, Gao Z, Baird L, Przeworski M, Jorde L, et al.
Elife
. 2019 Sep;
8.
PMID: 31549960
The number of de novo mutations (DNMs) found in an offspring's genome increases with both paternal and maternal age. But does the rate of mutation accumulation in human gametes differ...