Thomas A Pauly
Overview
Explore the profile of Thomas A Pauly including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
72
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0
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Recent Articles
1.
Siu M, Johnson T, Wang Y, Nair S, Taylor W, Cripps S, et al.
Bioorg Med Chem Lett
. 2009 May;
19(13):3493-7.
PMID: 19473839
N-(Pyridin-2-yl) arylsulfonamides are identified as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), an enzyme that catalyzes the reduction of the glucocorticoid cortisone to cortisol. Dysregulation of glucocorticoids has been implicated...
2.
Coburn S, Townsend D, Ericson K, Reynolds R, Ziegler P, Costill D, et al.
Adv Exp Med Biol
. 2004 Mar;
537:173-92.
PMID: 14995036
No abstract available.
3.
Pauly T, Ekstrom J, Beebe D, Chrunyk B, Cunningham D, Griffor M, et al.
Structure
. 2003 Sep;
11(9):1071-85.
PMID: 12962626
Sorbitol dehydrogenase (hSDH) and aldose reductase form the polyol pathway that interconverts glucose and fructose. Redox changes from overproduction of the coenzyme NADH by SDH may play a role in...
4.
Pauly T, Sulea T, Ammirati M, Sivaraman J, Danley D, Griffor M, et al.
Biochemistry
. 2003 Mar;
42(11):3203-13.
PMID: 12641451
Cathepsin S, a lysosomal cysteine protease of the papain superfamily, has been implicated in the preparation of MHC class II alphabeta-heterodimers for antigen presentation to CD4+ T lymphocytes and is...
5.
Ekstrom J, Pauly T, Carty M, Soeller W, Culp J, Danley D, et al.
Chem Biol
. 2002 Sep;
9(8):915-24.
PMID: 12204691
Human liver glycogen phosphorylase (HLGP) catalyzes the breakdown of glycogen to maintain serum glucose levels and is a therapeutic target for diabetes. HLGP is regulated by multiple interacting allosteric sites,...
6.
Coburn S, Reynolds R, Mahuren J, Schaltenbrand W, Wang Y, Ericson K, et al.
Am J Clin Nutr
. 2002 Jan;
75(1):57-64.
PMID: 11756060
Background: Renal insufficiency is associated with altered vitamin B-6 metabolism. We have observed high concentrations of 4-pyridoxic acid, the major catabolite of vitamin B-6 metabolism, in plasma during renal insufficiency....