Thomas A Leyen
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Explore the profile of Thomas A Leyen including associated specialties, affiliations and a list of published articles.
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5
Citations
122
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Recent Articles
1.
Szulcek R, Happe C, Rol N, Fontijn R, Dickhoff C, Hartemink K, et al.
Am J Respir Crit Care Med
. 2016 Jan;
193(12):1410-20.
PMID: 26760925
Rationale: Altered pulmonary hemodynamics and fluid flow-induced high shear stress (HSS) are characteristic hallmarks in the pathogenesis of pulmonary arterial hypertension (PAH). However, the contribution of HSS to cellular and...
2.
Favre J, Yildirim C, Leyen T, Chen W, van Genugten R, van Golen L, et al.
Vascul Pharmacol
. 2015 Aug;
75:7-18.
PMID: 26254104
A defect in neo-vascularization process involving circulating angiogenic mononuclear cells (CACs) dysfunction is associated with diabetes. We showed that oxidative stress was elevated in CACs cultured from blood of individuals...
3.
van Agtmaal E, Bierings R, Dragt B, Leyen T, Fernandez-Borja M, Horrevoets A, et al.
PLoS One
. 2012 Jun;
7(6):e38399.
PMID: 22715381
Background: The shear-stress induced transcription factor KLF2 has been shown to induce an atheroprotective phenotype in endothelial cells (EC) that are exposed to prolonged laminar shear. In this study we...
4.
van der Pouw Kraan T, Schirmer S, Fledderus J, Moerland P, Baggen J, Leyen T, et al.
BMC Genomics
. 2010 Jun;
11:388.
PMID: 20565948
Background: Circulating CD34+ progenitor cells have the potential to differentiate into a variety of cells, including endothelial cells. Knowledge is still scarce about the transcriptional programs used by CD34+ cells...
5.
Boon R, Leyen T, Fontijn R, Fledderus J, Baggen J, Volger O, et al.
Blood
. 2009 Dec;
115(12):2533-42.
PMID: 20032497
The shear stress-induced transcription factor Krüppel-like factor 2 (KLF2) confers antiinflammatory properties to endothelial cells through the inhibition of activator protein 1, presumably by interfering with mitogen-activated protein kinase (MAPK)...