Theodore R Cummins
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Explore the profile of Theodore R Cummins including associated specialties, affiliations and a list of published articles.
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104
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Recent Articles
1.
Frazee A, Zybura A, Cummins T
Cells
. 2025 Feb;
14(4).
PMID: 39996763
Fibroblast growth factor homologous factors (FHFs) regulate the activity of several different voltage-gated sodium channels (Nas). However, more work is needed to determine how specific FHF isoforms and variants affect...
2.
Xiao Y, Pan Y, Xiao J, Cummins T
Front Mol Neurosci
. 2024 Oct;
17:1433981.
PMID: 39416265
Introduction: Resurgent current ( ) generated by voltage-gated sodium channels (VGSCs) plays an essential role in maintaining high-frequency firing of many neurons and contributes to disease pathophysiology such as epilepsy...
3.
Gomes C, Huang K, Harkin J, Baker A, Hughes J, Pan Y, et al.
Stem Cell Reports
. 2024 Aug;
19(8):1122-1136.
PMID: 39094561
Reactive astrocytes are known to exert detrimental effects upon neurons in several neurodegenerative diseases, yet our understanding of how astrocytes promote neurotoxicity remains incomplete, especially in human systems. In this...
4.
Shin S, Itson-Zoske B, Fan F, Xiao Y, Qiu C, Cummins T, et al.
J Clin Invest
. 2024 May;
134(13).
PMID: 38722683
This study reports that targeting intrinsically disordered regions of the voltage-gated sodium channel 1.7 (NaV1.7) protein facilitates discovery of sodium channel inhibitory peptide aptamers (NaViPA) for adeno-associated virus-mediated (AAV-mediated), sensory...
5.
Zybura A, Sahoo F, Hudmon A, Cummins T
Cells
. 2022 Jul;
11(13).
PMID: 35805192
Aberrant Nav1.6 activity can induce hyperexcitability associated with epilepsy. Gain-of-function mutations in the gene encoding Nav1.6 are linked to epilepsy development; however, the molecular mechanisms mediating these changes are remarkably...
6.
Gomes C, VanderWall K, Pan Y, Lu X, Lavekar S, Huang K, et al.
Stem Cell Reports
. 2022 Jun;
17(7):1636-1649.
PMID: 35714595
Although the degeneration of retinal ganglion cells (RGCs) is a primary characteristic of glaucoma, astrocytes also contribute to their neurodegeneration in disease states. Although studies often explore cell-autonomous aspects of...
7.
George K, Lopez-Mateos D, Abd El-Aziz T, Xiao Y, Kline J, Bao H, et al.
Front Pharmacol
. 2022 Jun;
13:846992.
PMID: 35662692
Voltage-gated sodium channel Na1.8 regulates transmission of pain signals to the brain. While Na1.8 has the potential to serve as a drug target, the molecular mechanisms that shape Na1.8 gating...
8.
Hammer M, Pan Y, Cumbay M, Pendziwiat M, Afawi Z, Goldberg-Stern H, et al.
Epilepsia
. 2022 May;
63(8):1970-1980.
PMID: 35592948
Objective: Family members carrying the same SCN1A variant often exhibit differences in the clinical severity of epilepsy. This variable expressivity suggests that other factors aside from the primary sodium channel...
9.
Milder P, Zybura A, Cummins T, Marrs J
Front Pharmacol
. 2022 May;
13:836573.
PMID: 35496264
Approximately 30% of patients with epilepsy do not achieve adequate seizure control through current anti-seizure drugs and treatment methods. Therefore, a critical need exists to efficiently screen anti-seizure drugs to...
10.
Xiao Y, Theile J, Zybura A, Pan Y, Lin Z, Cummins T
Elife
. 2022 Apr;
11.
PMID: 35441593
Resurgent currents () produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the...