Thai Leong Yap
Overview
Explore the profile of Thai Leong Yap including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
729
Followers
0
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Recent Articles
1.
Yap T, Hong S, Soh J, Ravichandraprabhu L, Lim V, Chan H, et al.
Emerg Infect Dis
. 2021 Apr;
27(5):1427-1437.
PMID: 33900180
Dengue virus (DENV) and Zika virus (ZIKV) belong to the Flaviviridae family of viruses spread by Aedes aegypti mosquitoes in tropical and subtropical areas. Accurate diagnostic tests to differentiate the...
2.
Rostovtseva T, Gurnev P, Protchenko O, Hoogerheide D, Yap T, Philpott C, et al.
J Biol Chem
. 2015 Jun;
290(30):18467-77.
PMID: 26055708
Participation of the small, intrinsically disordered protein α-synuclein (α-syn) in Parkinson disease (PD) pathogenesis has been well documented. Although recent research demonstrates the involvement of α-syn in mitochondrial dysfunction in...
3.
Gruschus J, Jiang Z, Yap T, Hill S, Grishaev A, Piszczek G, et al.
Biochem Biophys Res Commun
. 2015 Jan;
457(4):561-6.
PMID: 25600808
Mutations in the gene for the lysosomal enzyme glucocerebrosidase (GCase) cause Gaucher disease and are the most common risk factor for Parkinson disease (PD). Analytical ultracentrifugation of 8 μM GCase...
4.
Yap T, Jiang Z, Heinrich F, Gruschus J, Pfefferkorn C, Barros M, et al.
J Biol Chem
. 2014 Nov;
290(2):744-54.
PMID: 25429104
Mutations in glucocerebrosidase (GCase), the enzyme deficient in Gaucher disease, are a common genetic risk factor for the development of Parkinson disease and related disorders, implicating the role of this...
5.
Gurnev P, Yap T, Pfefferkorn C, Rostovtseva T, Berezhkovskii A, Lee J, et al.
Biophys J
. 2014 Feb;
106(3):556-65.
PMID: 24507596
Gauging the interactions of a natively unfolded Parkinson disease-related protein, alpha-synuclein (α-syn) with membranes and its pathways between and within cells is important for understanding its pathogenesis. Here, to address...
6.
Yap T, Gruschus J, Velayati A, Sidransky E, Lee J
Biochemistry
. 2013 Sep;
52(41):7161-3.
PMID: 24070323
Mutations in GBA1, the gene for glucocerebrosidase (GCase), are genetic risk factors for Parkinson disease (PD). α-Synuclein (α-Syn), a protein implicated in PD, interacts with GCase and efficiently inhibits enzyme...
7.
Gruschus J, Yap T, Pistolesi S, Maltsev A, Lee J
Biochemistry
. 2013 Apr;
52(20):3436-45.
PMID: 23607618
Calmodulin (CaM) is a calcium binding protein that plays numerous roles in Ca-dependent cellular processes, including uptake and release of neurotransmitters in neurons. α-Synuclein (α-syn), one of the most abundant...
8.
Yap T, Velayati A, Sidransky E, Lee J
Mol Genet Metab
. 2012 Dec;
108(1):56-64.
PMID: 23266198
Mutations in GBA, the gene encoding glucocerebrosidase, the lysosomal enzyme deficient in Gaucher disease increase the risk for developing Parkinson disease. Recent research suggests a relationship between glucocerebrosidase and the...
9.
McGlinchey R, Yap T, Lee J
Phys Chem Chem Phys
. 2011 Oct;
13(45):20066-75.
PMID: 21993592
Amyloid has been traditionally viewed in the context of disease. However, the emerging concept of 'functional amyloid' has taken a new direction into how we view amyloid. Recent studies have...
10.
Yap T, Gruschus J, Velayati A, Westbroek W, Goldin E, Moaven N, et al.
J Biol Chem
. 2011 Jun;
286(32):28080-8.
PMID: 21653695
The presynaptic protein α-synuclein (α-syn), particularly in its amyloid form, is widely recognized for its involvement in Parkinson disease (PD). Recent genetic studies reveal that mutations in the gene GBA...