Tess C Lengyell
Overview
Explore the profile of Tess C Lengyell including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
102
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0
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Recent Articles
1.
Gibson W, Lengyell T, Korecki A, Janssen S, Adair B, Gamu D, et al.
Hum Gene Ther
. 2025 Feb;
36(5-6):618-627.
PMID: 39964768
Weaver syndrome is a rare neurodevelopmental disorder that encompasses macrocephaly, tall stature, obesity, brain anomalies, intellectual disability, and increased susceptibility to cancer. This dominant monogenic disorder is caused by germline...
2.
Crombie E, Korecki A, Cleverley K, Adair B, Cunningham T, Lee W, et al.
Dis Model Mech
. 2024 May;
17(7).
PMID: 38804708
The TATA box-binding protein-associated factor 1 (TAF1) is a ubiquitously expressed protein and the largest subunit of the basal transcription factor TFIID, which plays a key role in initiation of...
3.
Golla K, Paul M, Lengyell T, Simpson E, Falet H, Kim H
Res Pract Thromb Haemost
. 2023 Aug;
7(4):100019.
PMID: 37538498
Background And Objective: The molecular mechanisms that underpin platelet granule secretion remain poorly defined. Filamin A (FLNA) is an actin-crosslinking and signaling scaffold protein whose role in granule exocytosis has...
4.
Adair B, Korecki A, Djaksigulova D, Wagner P, Chiu N, Ling Lam S, et al.
Ophthalmol Ther
. 2023 May;
12(4):2049-2068.
PMID: 37210469
Introduction: Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to...
5.
Al-Shekaili H, L Petkau T, Pena I, Lengyell T, Verhoeven-Duif N, Ciapaite J, et al.
Hum Mol Genet
. 2020 Sep;
29(19):3266-3284.
PMID: 32969477
Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disease caused by mutations in the ALDH7A1 gene leading to blockade of the lysine catabolism pathway. PDE is characterized by recurrent seizures...
6.
Mirjalili Mohanna S, Hickmott J, Ling Lam S, Chiu N, Lengyell T, Tam B, et al.
Mol Ther Methods Clin Dev
. 2020 Apr;
17:478-490.
PMID: 32258211
Aniridia is a rare eye disorder, which is caused by mutations in the paired box 6 () gene and results in vision loss due to the lack of a long-term...
7.
Connell M, Chen H, Jiang J, Kuan C, Fotovati A, Chu T, et al.
Elife
. 2017 Oct;
6.
PMID: 28994651
Oriented cell division is one mechanism progenitor cells use during development and to maintain tissue homeostasis. Common to most cell types is the asymmetric establishment and regulation of cortical NuMA-dynein...
8.
de Leeuw C, Korecki A, Berry G, Hickmott J, Ling Lam S, Lengyell T, et al.
Mol Brain
. 2016 May;
9(1):52.
PMID: 27164903
Background: Small promoters that recapitulate endogenous gene expression patterns are important for basic, preclinical, and now clinical research. Recently, there has been a promising revival of gene therapy for diseases...