Elizabeth M Simpson
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Explore the profile of Elizabeth M Simpson including associated specialties, affiliations and a list of published articles.
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63
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2204
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Recent Articles
1.
Gibson W, Lengyell T, Korecki A, Janssen S, Adair B, Gamu D, et al.
Hum Gene Ther
. 2025 Feb;
36(5-6):618-627.
PMID: 39964768
Weaver syndrome is a rare neurodevelopmental disorder that encompasses macrocephaly, tall stature, obesity, brain anomalies, intellectual disability, and increased susceptibility to cancer. This dominant monogenic disorder is caused by germline...
2.
de Moura Gomes A, L Petkau T, Korecki A, Fornes O, Galvan A, Lu G, et al.
Sci Rep
. 2024 Nov;
14(1):28194.
PMID: 39548191
Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2...
3.
Crombie E, Korecki A, Cleverley K, Adair B, Cunningham T, Lee W, et al.
Dis Model Mech
. 2024 May;
17(7).
PMID: 38804708
The TATA box-binding protein-associated factor 1 (TAF1) is a ubiquitously expressed protein and the largest subunit of the basal transcription factor TFIID, which plays a key role in initiation of...
4.
Lanza D, Mao J, Lorenzo I, Liao L, Seavitt J, Ljungberg M, et al.
Genesis
. 2024 Mar;
62(2):e23589.
PMID: 38523431
Cas9 transgenes can be employed for genome editing in mouse zygotes. However, using transgenic instead of exogenous Cas9 to produce gene-edited animals creates unique issues including ill-defined transgene integration sites,...
5.
Golla K, Paul M, Lengyell T, Simpson E, Falet H, Kim H
Res Pract Thromb Haemost
. 2023 Aug;
7(4):100019.
PMID: 37538498
Background And Objective: The molecular mechanisms that underpin platelet granule secretion remain poorly defined. Filamin A (FLNA) is an actin-crosslinking and signaling scaffold protein whose role in granule exocytosis has...
6.
Simpson E, Clarke I, Scott C, Stephen C, Rao A, Gunn A
J Endocrinol
. 2023 Jul;
259(1).
PMID: 37466202
Our previous studies showed that microinjection into the median eminence of the sheep of glucagon-like peptide- 1 (GLP-1) or its receptor agonist exendin-4 stimulates luteinising hormone (LH) secretion, but it...
7.
Adair B, Korecki A, Djaksigulova D, Wagner P, Chiu N, Ling Lam S, et al.
Ophthalmol Ther
. 2023 May;
12(4):2049-2068.
PMID: 37210469
Introduction: Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to...
8.
Fornes O, Av-Shalom T, Korecki A, A Farkas R, Arenillas D, Mathelier A, et al.
Nucleic Acids Res
. 2023 May;
51(W1):W379-W386.
PMID: 37166953
MiniPromoters, or compact promoters, are short DNA sequences that can drive expression in specific cells and tissues. While broadly useful, they are of high relevance to gene therapy due to...
9.
Mirjalili Mohanna S, Korecki A, Simpson E
Gene Ther
. 2023 Apr;
30(9):670-684.
PMID: 37072572
Recently safety concerns have been raised in connection with high doses of recombinant adeno-associated viruses (rAAV). Therefore, we undertook a series of experiments to test viral capsid (rAAV9 and rAAV-PHP.B),...
10.
Kofoed R, Simpson E, Hynynen K, Aubert I
Gene Ther
. 2023 Feb;
30(12):807-811.
PMID: 36781945
Transcranial ultrasound combined with intravenous microbubbles can be used to increase blood-brain barrier permeability or, at lower pressures, to mediate sonoselective gene delivery to endothelial cells. Previously, sonoselective gene delivery...