Terrence F Meehan
Overview
Explore the profile of Terrence F Meehan including associated specialties, affiliations and a list of published articles.
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42
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5762
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Recent Articles
1.
Spielmann N, Miller G, Oprea T, Hsu C, Fobo G, Frishman G, et al.
Nat Cardiovasc Res
. 2024 Aug;
1(2):157-173.
PMID: 39195995
Clinical presentation of congenital heart disease is heterogeneous, making identification of the disease-causing genes and their genetic pathways and mechanisms of action challenging. By using in vivo electrocardiography, transthoracic echocardiography...
2.
Birling M, Yoshiki A, Adams D, Ayabe S, Beaudet A, Bottomley J, et al.
Nat Genet
. 2021 Apr;
53(4):416-419.
PMID: 33833456
No abstract available.
3.
Haselimashhadi H, Mason J, Mallon A, Smedley D, Meehan T, Parkinson H
PLoS One
. 2020 Dec;
15(12):e0242933.
PMID: 33378393
Reproducibility in the statistical analyses of data from high-throughput phenotyping screens requires a robust and reliable analysis foundation that allows modelling of different possible statistical scenarios. Regular challenges are scalability...
4.
Swan A, Schutt C, Rozman J, Muniz Moreno M, Brandmaier S, Simon M, et al.
PLoS Genet
. 2020 Dec;
16(12):e1009190.
PMID: 33370286
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for...
5.
Stevens I, Mukarram A, Hortenhuber M, Meehan T, Rung J, Daub C
PLoS Comput Biol
. 2020 Oct;
16(10):e1008260.
PMID: 33017400
No abstract available.
6.
Lloyd K, Adams D, Baynam G, Beaudet A, Bosch F, Boycott K, et al.
Genome Biol
. 2020 Feb;
21(1):18.
PMID: 32008577
No abstract available.
7.
Cacheiro P, Munoz-Fuentes V, Murray S, Dickinson M, Bucan M, Nutter L, et al.
Nat Commun
. 2020 Feb;
11(1):655.
PMID: 32005800
The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene...
8.
Abeler-Dorner L, Laing A, Lorenc A, Ushakov D, Clare S, Speak A, et al.
Nat Immunol
. 2019 Dec;
21(1):86-100.
PMID: 31844327
By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation (http://www.immunophenotype.org). Specifically, high-throughput phenotyping of 530...
9.
Haselimashhadi H, Mason J, Munoz-Fuentes V, Lopez-Gomez F, Babalola K, Acar E, et al.
Bioinformatics
. 2019 Oct;
36(5):1492-1500.
PMID: 31591642
Motivation: High-throughput phenomic projects generate complex data from small treatment and large control groups that increase the power of the analyses but introduce variation over time. A method is needed...
10.
Meehan T
Cancer Res
. 2019 Sep;
79(17):4324-4325.
PMID: 31481418
Patient-derived tumor xenograft (PDX) models are frequently used to study cancer mechanisms and potential therapeutics, however, differences in tumor evolution between models and patients have called into question their clinical...