Tatyana Kareva
Overview
Explore the profile of Tatyana Kareva including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
415
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0
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Recent Articles
1.
Goldman C, Kareva T, Sarrafha L, Schuldt B, Sahasrabudhe A, Ahfeldt T, et al.
bioRxiv
. 2024 Jul;
PMID: 38979135
Cellular processes including lysosomal and mitochondrial dysfunction are implicated in the development of many diseases. Quantitative visualization of mitochondria and lysosoesl is crucial to understand how these organelles are dysregulated...
2.
Ferreira A, Hemmer B, Philippi S, Grau-Perales A, Rosenstadt J, Liu H, et al.
Mol Psychiatry
. 2023 Nov;
28(9):3943-3954.
PMID: 37914840
Functional output of the hippocampus, a brain region subserving memory function, depends on highly orchestrated cellular and molecular processes that regulate synaptic plasticity throughout life. The structural requirements of such...
3.
Sarrafha L, Neavin D, Parfitt G, Kruglikov I, Whitney K, Reyes R, et al.
iScience
. 2023 Aug;
26(9):107525.
PMID: 37646018
The hypothalamus is a region of the brain that plays an important role in regulating body functions and behaviors. There is a growing interest in human pluripotent stem cells (hPSCs)...
4.
Sarrafha L, Parfitt G, Reyes R, Goldman C, Coccia E, Kareva T, et al.
STAR Protoc
. 2021 May;
2(2):100463.
PMID: 33997803
Here, we describe a high-throughput 3D differentiation protocol for deriving midbrain dopaminergic neurons from human pluripotent stem cells. The use of organoids has become prevalent in disease modeling, but there...
5.
Park S, Burke R, Kareva T, Kholodilov N, Aime P, Franke T, et al.
PLoS One
. 2018 Jun;
13(6):e0197899.
PMID: 29920520
Akt kinases are key signaling components in proliferation-competent and post-mitotic cells. Here, we sought to create a conditionally-inducible form of active Akt for both in vitro and in vivo applications....
6.
Rolland A, Kareva T, Kholodilov N, Burke R
Neuroscience
. 2017 Jan;
346:126-134.
PMID: 28108256
Adeno-associated viruses (AAVs) have become powerful tools in neuroscience for both basic research and potential therapeutic use. They have become especially important tools for optogenetic experiments based on their ability...
7.
Rolland A, Kareva T, Yarygina O, Kholodilov N, Burke R
Mol Ther Methods Clin Dev
. 2016 Oct;
3:16062.
PMID: 27689101
The use of viral vectors to transfect postmitotic neurons has provided an important research tool, and it offers promise for treatment of neurologic disease. The utility of vectors is enhanced...
8.
Tagliaferro P, Kareva T, Oo T, Yarygina O, Kholodilov N, Burke R
Neurobiol Dis
. 2015 Jul;
82:359-371.
PMID: 26192625
Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease (PD) and patients with these mutations manifest clinical features that are indistinguishable from those of...
9.
Chen X, Tagliaferro P, Kareva T, Yarygina O, Kholodilov N, Burke R
J Neurosci
. 2012 Aug;
32(33):11299-308.
PMID: 22895713
Mesencephalic dopamine neurons are central to many aspects of human cognition, motivational, and motor behavior, and they are uniquely vulnerable to degenerative neurologic disorders such as Parkinson's disease. There is...
10.
Kim S, Kareva T, Yarygina O, Kholodilov N, Burke R
Mol Ther
. 2011 Oct;
20(2):275-86.
PMID: 22008911
There are currently no therapies that provide either protection or restoration of neuronal function for adult-onset neurodegenerative diseases such as Parkinson's disease (PD). Many clinical efforts to provide such benefits...