Tinmarla F Oo
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Explore the profile of Tinmarla F Oo including associated specialties, affiliations and a list of published articles.
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10
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584
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Recent Articles
1.
Dragich J, Kuwajima T, Hirose-Ikeda M, Yoon M, Eenjes E, Bosco J, et al.
Elife
. 2016 Sep;
5.
PMID: 27648578
The regulation of protein degradation is essential for maintaining the appropriate environment to coordinate complex cell signaling events and to promote cellular remodeling. The Autophagy linked FYVE protein (Alfy), previously...
2.
Tagliaferro P, Kareva T, Oo T, Yarygina O, Kholodilov N, Burke R
Neurobiol Dis
. 2015 Jul;
82:359-371.
PMID: 26192625
Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease (PD) and patients with these mutations manifest clinical features that are indistinguishable from those of...
3.
Kim S, Ries V, Cheng H, Kareva T, Oo T, Yu W, et al.
Neurobiol Dis
. 2011 Jul;
44(2):215-22.
PMID: 21782946
The mechanisms underlying the chronic neurodegeneration that occurs in Parkinson's disease (PD) are unknown. One emerging hypothesis is that neural systems deteriorate and eventually degenerate due to a primary failure...
4.
Kim S, Chen X, Oo T, Kareva T, Yarygina O, Wang C, et al.
Ann Neurol
. 2011 Mar;
70(1):110-20.
PMID: 21437936
Objective: A prevailing concept in neuroscience has been that the adult mammalian central nervous system is incapable of restorative axon regeneration. Recent evidence, however, has suggested that reactivation of intrinsic...
5.
Cheng H, Kim S, Oo T, Kareva T, Yarygina O, Rzhetskaya M, et al.
J Neurosci
. 2011 Feb;
31(6):2125-35.
PMID: 21307249
Axon degeneration is a hallmark of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Such degeneration is not a passive event but rather an active process mediated by mechanisms that...
6.
Li Y, Liu W, Oo T, Wang L, Tang Y, Jackson-Lewis V, et al.
Nat Neurosci
. 2009 Jun;
12(7):826-8.
PMID: 19503083
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease:...
7.
Ries V, Cheng H, Baohan A, Kareva T, Oo T, Rzhetskaya M, et al.
J Neurochem
. 2009 Jun;
110(1):23-33.
PMID: 19490361
Following mitosis, specification and migration during embryogenesis, dopamine neurons of the mesencephalon undergo a postnatal naturally occurring cell death event that determines their final adult number, and a period of...
8.
Oo T, Marchionini D, Yarygina O, OLeary P, Hughes R, Kholodilov N, et al.
Mol Cell Neurosci
. 2009 May;
41(4):440-7.
PMID: 19409492
Brain-derived neurotrophic factor (BDNF) was the first purified molecule identified to directly support the development of mesencephalic dopamine neurons. However, its physiologic role has remained unknown. Based on patterns of...
9.
Ries V, Silva R, Oo T, Cheng H, Rzhetskaya M, Kholodilov N, et al.
J Neurochem
. 2008 Nov;
107(6):1578-88.
PMID: 19014392
Activation of c-jun N-terminal kinase (JNK) by the mitogen-activated protein kinase cascade has been shown to play an important role in the death of dopamine neurons of the substantia nigra,...
10.
Oo T, Siman R, Burke R
Exp Neurol
. 2002 May;
175(1):1-9.
PMID: 12009755
An emerging theme in programmed cell death (PCD) of neurons is that the mechanisms involved depend on the cellular context and the death-inducing stimulus. One particular class of neurons for...