Tatyana I Igumenova
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Explore the profile of Tatyana I Igumenova including associated specialties, affiliations and a list of published articles.
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40
Citations
643
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Recent Articles
1.
Chen X, Dixit K, Yang Y, McDermott M, Imam H, Bankaitis V, et al.
Elife
. 2024 Apr;
13.
PMID: 38687676
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Members of the lipid-activated protein kinase...
2.
Katti S, Igumenova T
bioRxiv
. 2024 Feb;
PMID: 38405767
One of the mechanisms by which toxic metal ions interfere with cellular functions is ionic mimicry, where they bind to protein sites in lieu of native metals Ca and Zn...
3.
Chen X, Dixit K, Yang Y, McDermott M, Imam H, Bankaitis V, et al.
bioRxiv
. 2023 Oct;
PMID: 37781616
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Members of the lipid-activated protein kinase...
4.
Chen X, Poudel L, Hong Z, Johnen P, Katti S, Tripathi A, et al.
J Biol Chem
. 2023 Jan;
299(2):102861.
PMID: 36603766
Phosphatidylinositol (PtdIns) transfer proteins (PITPs) enhance the activities of PtdIns 4-OH kinases that generate signaling pools of PtdIns-4-phosphate. In that capacity, PITPs serve as key regulators of lipid signaling in...
5.
Chen X, Igumenova T
Adv Biol Regul
. 2022 Dec;
87:100938.
PMID: 36496344
The peptidyl-prolyl isomerase Pin1 cooperates with proline-directed kinases and phosphatases to regulate multiple oncogenic pathways. Pin1 specifically recognizes phosphorylated Ser/Thr-Pro motifs in proteins and catalyzes their cis-trans isomerization. The Pin1-catalyzed...
6.
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
Katti S, Krieger I, Ann J, Lee J, Sacchettini J, Igumenova T
Nat Commun
. 2022 May;
13(1):2695.
PMID: 35577811
Diacylglycerol (DAG) is a versatile lipid whose 1,2-sn-stereoisomer serves both as second messenger in signal transduction pathways that control vital cellular processes, and as metabolic precursor for downstream signaling lipids...
7.
Bankaitis V, Tripathi A, Chen X, Igumenova T
Adv Biol Regul
. 2022 Mar;
84:100891.
PMID: 35240534
Virulent fungi represent a particularly difficult problem in the infectious disease arena as these organisms are eukaryotes that share many orthologous activities with their human hosts. The fact that these...
8.
Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy
Cole T, Igumenova T
Front Mol Biosci
. 2021 Aug;
8:728711.
PMID: 34447788
Conserved homology 1 (C1) domains are peripheral zinc finger domains that are responsible for recruiting their host signaling proteins, including Protein Kinase C (PKC) isoenzymes, to diacylglycerol-containing lipid membranes. In...
9.
You Y, Katti S, Yu B, Igumenova T, Das J
Biochemistry
. 2021 Apr;
60(16):1286-1298.
PMID: 33818064
Munc13-1 is a presynaptic active zone protein that acts as a master regulator of synaptic vesicle priming and neurotransmitter release in the brain. It has been implicated in the pathophysiology...
10.
Katti S, Igumenova T
Adv Biol Regul
. 2021 Feb;
79:100784.
PMID: 33526356
Protein Kinase C isoenzymes (PKCs) are the key mediators of the phosphoinositide signaling pathway, which involves regulated hydrolysis of phosphatidylinositol (4,5)-bisphosphate to diacylglycerol (DAG) and inositol-1,4,5-trisphosphate. Dysregulation of PKCs is...