Pingwei Li
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Explore the profile of Pingwei Li including associated specialties, affiliations and a list of published articles.
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81
Citations
3825
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Recent Articles
1.
Li H, Cai H, Li P, Zeng Y, Zhang Y
Clin Cosmet Investig Dermatol
. 2025 Feb;
18:445-451.
PMID: 40012868
Background: Androgenetic alopecia (AGA) is the most common form of alopecia globally, which exerts a negative impact on patients' self-esteem and overall quality of life. Previous observational studies have found...
2.
Wu L, Yan Y, Yuan Y, Zhao Z, Qu W, Huang X, et al.
mBio
. 2025 Feb;
:e0339524.
PMID: 39998223
Importance: Cyclic GMP-AMP synthetase (cGAS) is robustly expressed in the nucleus and tightly tethered by chromatin to prevent its activation with self-DNA. During stimulation or infection, nuclear cGAS is activated...
3.
Qiu L, Li P, Ding Z, Wang J, Huang N, Hua L, et al.
Sleep Breath
. 2025 Feb;
29(1):94.
PMID: 39928206
Purpose: Obstructive sleep apnea (OSA) is prevalent in patients with cardiovascular disease (CVD), and is linked to worsened outcomes. Screening tools are essential for early detection and intervention. We aimed...
4.
Shinde O, Boyer J, Cambier S, VanPortfliet J, Sui X, Yadav G, et al.
Immunity
. 2025 Jan;
58(1):59-73.e5.
PMID: 39765229
Cyclic nucleotide GMP-AMP (cGAMP) plays a critical role in mediating the innate immune response through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. Recent studies showed that ATP-binding...
5.
Li M, Zhu C, Yuan Y, Huang X, Wu L, Wu J, et al.
iScience
. 2024 Nov;
27(11):111145.
PMID: 39524340
Host immune system has evolved multiple sensors to detect pathogenic and damaged DNA, where precise regulation is critical for distinguishing self from non-self. Our previous studies showed that NLRC3 is...
6.
Yin H, Zhao Z, Yan Y, Yuan Y, Qu W, Wang H, et al.
mBio
. 2024 Aug;
15(10):e0168024.
PMID: 39207099
Importance: Gasdermin A (GSDMA) remains a protein shrouded in mystery, particularly regarding its regulation by virus-encoded proteases. Previous studies have identified human GSDMA (hGSDMA) as a sensor and substrate of...
7.
Huang X, Zhao Z, Zhu C, Chai L, Yan Y, Yuan Y, et al.
PLoS Pathog
. 2024 Jul;
20(7):e1012398.
PMID: 39038050
Inflammasomes play pivotal roles in inflammation by processing and promoting the secretion of IL-1β. Caspase-1 is involved in the maturation of IL-1β and IL-18, while human caspase-4 specifically processes IL-18....
8.
Shinde O, Li P
Adv Immunol
. 2024 Jun;
162:1-21.
PMID: 38866436
Double stranded DNA (dsDNA) in the cytoplasm triggers the cGAS-STING innate immune pathway to defend against pathogenic infections, tissue damage and malignant cells. Extensive structural and functional studies over the...
9.
Tang Z, Zhao J, Li Y, Tomer S, Selvaraju M, Tien N, et al.
ACS Med Chem Lett
. 2024 May;
15(5):653-658.
PMID: 38746895
Previously we identified a non-nucleotide agonist BDW568 that selectively activates the human STING allele. Here, we further characterized the mechanism of BDW568 and highlighted its potential use for selectively controlling...
10.
Xi Q, Liu Z, Xiong C, Luo Q, Zhao Z, Zhao Q, et al.
Pulm Circ
. 2023 Dec;
13(4):e12313.
PMID: 38075014
Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study,...