Tatsuya Morisaki
Overview
Explore the profile of Tatsuya Morisaki including associated specialties, affiliations and a list of published articles.
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33
Citations
1214
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Recent Articles
1.
Galindo G, Maejima D, DeRoo J, Burlingham S, Fixen G, Morisaki T, et al.
bioRxiv
. 2025 Feb;
PMID: 39975170
Intrabodies are engineered antibodies that function inside living cells, enabling therapeutic, diagnostic, and imaging applications. While powerful, their development has been hindered by challenges associated with their folding, solubility, and...
2.
Lyon K, Morisaki T, Stasevich T
Methods Mol Biol
. 2024 Nov;
2875:99-110.
PMID: 39535643
Recent advances in fluorescence microscopy have now made it possible to measure the translation dynamics of individual RNA in living cells and in multiple colors. Here we describe a protocol...
3.
Morisaki T, Wiggan O, Stasevich T
Annu Rev Biophys
. 2023 Dec;
53(1):65-85.
PMID: 38134333
The translation of messenger RNA (mRNA) into proteins represents the culmination of gene expression. Recent technological advances have revolutionized our ability to investigate this process with unprecedented precision, enabling the...
4.
Saxton M, Morisaki T, Krapf D, Kimura H, Stasevich T
Sci Adv
. 2023 Oct;
9(40):eadh4819.
PMID: 37792937
Histone acetylation and RNA polymerase II phosphorylation are associated with transcriptionally active chromatin, but their spatiotemporal relationship in live cells remains poorly understood. To address this problem, we combine Fab-based...
5.
Raymond W, Ghaffari S, Aguilera L, Ron E, Morisaki T, Fox Z, et al.
Front Cell Dev Biol
. 2023 Jun;
11:1151318.
PMID: 37325568
mRNA translation is the ubiquitous cellular process of reading messenger-RNA strands into functional proteins. Over the past decade, large strides in microscopy techniques have allowed observation of mRNA translation at...
6.
Raymond W, Ghaffari S, Aguilera L, Ron E, Morisaki T, Fox Z, et al.
bioRxiv
. 2023 Feb;
PMID: 36747627
mRNA translation is the ubiquitous cellular process of reading messenger-RNA strands into functional proteins. Over the past decade, large strides in microscopy techniques have allowed observation of mRNA translation at...
7.
Cialek C, Galindo G, Morisaki T, Zhao N, Montgomery T, Stasevich T
Nat Commun
. 2022 Jun;
13(1):3345.
PMID: 35688806
A major challenge to our understanding of translational control has been deconvolving the individual impact specific regulatory factors have on the complex dynamics of mRNA translation. MicroRNAs (miRNAs), for example,...
8.
Morisaki T, Stasevich T
Methods Mol Biol
. 2022 Feb;
2428:349-360.
PMID: 35171490
Single-molecule imaging in living cells enables the investigation of molecular dynamics and interactions underlying the physiology of a cell. We recently developed a method to visualize translation events at single-mRNA...
9.
Koch A, Morisaki T, Stasevich T
Bio Protoc
. 2021 Aug;
11(14):e4096.
PMID: 34395732
Here, we describe how to image and quantitate the translation dynamics of a bicistronic biosensor that we recently created to fairly compare cap-dependent and IRES-mediated translation at single-molecule resolution in...
10.
Forero-Quintero L, Raymond W, Handa T, Saxton M, Morisaki T, Kimura H, et al.
Nat Commun
. 2021 May;
12(1):3158.
PMID: 34039974
The carboxyl-terminal domain of RNA polymerase II (RNAP2) is phosphorylated during transcription in eukaryotic cells. While residue-specific phosphorylation has been mapped with exquisite spatial resolution along the 1D genome in...