Davide Mazza
Overview
Explore the profile of Davide Mazza including associated specialties, affiliations and a list of published articles.
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Articles
58
Citations
1590
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Recent Articles
1.
Fedkenheuer M, Shang Y, Jung S, Fedkenheuer K, Park S, Mazza D, et al.
Nat Commun
. 2025 Jan;
16(1):843.
PMID: 39833168
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental...
2.
Fillot T, Mazza D
Curr Opin Genet Dev
. 2024 Dec;
90:102299.
PMID: 39705880
The genome is traditionally divided into condensed heterochromatin and open euchromatin. However, recent findings challenge this binary classification and the notion that chromatin condensation solely governs the accessibility of transcription...
3.
Simoni M, Menegazzi C, Fracassi C, Biffi C, Genova F, Tenace N, et al.
EMBO Mol Med
. 2024 May;
16(6):1324-1351.
PMID: 38730056
Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild-type p53 protein is implicated...
4.
Mazzocca M, Loffreda A, Colombo E, Fillot T, Gnani D, Falletta P, et al.
Nat Commun
. 2023 Oct;
14(1):6433.
PMID: 37833263
Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization in such search is uncharted. Here we analyzed how multiple factors explore chromatin, combining live-cell...
5.
Fracassi C, Ugge M, Abdelhalim M, Zapparoli E, Simoni M, Magliulo D, et al.
Nucleic Acids Res
. 2023 Oct;
51(20):11024-11039.
PMID: 37823593
The promyelocytic leukemia (PML) protein organizes nuclear aggregates known as PML nuclear bodies (PML-NBs), where many transcription factors localize to be regulated. In addition, associations of PML and PML-NBs with...
6.
Louphrasitthiphol P, Loffreda A, Pogenberg V, Picaud S, Schepsky A, Friedrichsen H, et al.
Nat Commun
. 2023 Sep;
14(1):6051.
PMID: 37770430
The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis. How this is achieved...
7.
Donnaloja F, Raimondi M, Messa L, Barzaghini B, Carnevali F, Colombo E, et al.
APL Bioeng
. 2023 Sep;
7(3):036112.
PMID: 37692376
Mechanical stimuli from the extracellular environment affect cell morphology and functionality. Recently, we reported that mesenchymal stem cells (MSCs) grown in a custom-made 3D microscaffold, the Nichoid, are able to...
8.
Colombo E, Di Dario M, Menon R, Valente M, Bassani C, Sarno N, et al.
J Autoimmun
. 2023 May;
138:103053.
PMID: 37236124
Hepatocyte nuclear factor 4 α (HNF4α), a transcription factor (TF) essential for embryonic development, has been recently shown to regulate the expression of inflammatory genes. To characterize HNF4a function in...
9.
Cantoni E, Merelli I, Stefanoni D, Tomelleri A, Campochiaro C, Giordano V, et al.
Rheumatology (Oxford)
. 2023 Feb;
62(10):3469-3479.
PMID: 36802235
Objective: Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective...
10.
Gritti I, Basso V, Rinchai D, Corigliano F, Pivetti S, Gaviraghi M, et al.
EMBO J
. 2022 Oct;
41(22):e108040.
PMID: 36215697
The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear....