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» Authors » Tarek H Afifi

Tarek H Afifi

Explore the profile of Tarek H Afifi including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 133
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Rawda M Okasha
Ahmed M Fouda
Ahmed M El-Agrody
Fawzia F Alblewi
Hany E A Ahmed
Ahmed Mora
Al-Anood M Al-Dies
Alaa S Abd-El-Aziz
Arshi Naqvi
Mosa H Alsehli
Published In
Bioorg Chem
Molecules
Int J Mol Sci
EXCLI J
Chem Commun (Camb)
Affiliations
Soon will be listed here.
Recent Articles
11.
First example of Azo-Sulfa conjugated chromene moieties: Synthesis, characterization, antimicrobial assessment, docking simulation as potent class I histone deacetylase inhibitors and antitumor agents
Okasha R, Alsehli M, Ihmaid S, Althagfan S, El-Gaby M, Ahmed H, et al.
Bioorg Chem . 2019 Sep; 92:103262. PMID: 31518757
This report presents the development of a novel and primary model of sulfonamide compounds encompassing a chromene azo motif with the intent of becoming applicable for drug candidates in the...
12.
Design of Thermochromic Polynorbornene Bearing Spiropyran Chromophore Moieties: Synthesis, Thermal Behavior and Dielectric Barrier Discharge Plasma Treatment
Ahmed S, Okasha R, Khairou K, Afifi T, Mohamed A, Abd-El-Aziz A
Polymers (Basel) . 2019 Apr; 9(11). PMID: 30965934
A new class of thermochromic polynorbornene with pendent spiropyran moieties has been synthesized. Functionalization of norbornene monomers with spirobenzopyran moieties has been achieved using Steglich esterification. These new monomeric materials...
13.
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene
Alblewi F, Okasha R, Hritani Z, Mohamed H, El-Nassag M, Halawa A, et al.
Bioorg Chem . 2019 Apr; 87:560-571. PMID: 30928878
Novel β-enaminonitrile/ester compounds (4, 6) and an imidate of 4 (9) were utilized as key scaffolds for the synthesis of newly 2-substituted 4H-benzo[h]chromene (7, 8, 10, 11, 13, 14) and...
14.
Design and Synthesis of Novel Heterocyclic-Based 4-benzo[]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis
Alblewi F, Okasha R, Eskandrani A, Afifi T, Mohamed H, Halawa A, et al.
Molecules . 2019 Mar; 24(6). PMID: 30889862
Novel fused chromenes (,⁻) and pyrimidines (⁻) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon cancer (HCT-116), and liver cancer (HepG-2) activities. The structural...
15.
Introducing novel potent anticancer agents of 1H-benzo[f]chromene scaffolds, targeting c-Src kinase enzyme with MDA-MB-231 cell line anti-invasion effect
Ahmed H, El-Nassag M, Hassan A, Okasha R, Ihmaid S, Fouda A, et al.
J Enzyme Inhib Med Chem . 2018 Jun; 33(1):1074-1088. PMID: 29923425
In our effort to develop novel and powerful agents with anti-proliferative activity, two new series of 1H-benzo[f]chromene derivatives, 4a-h and 6a-h, were synthesised using heterocyclocondensation methodologies under microwave irradiation condition....
16.
Structure-activity relationships and molecular docking studies of chromene and chromene based azo chromophores: A novel series of potent antimicrobial and anticancer agents
Afifi T, Okasha R, Ahmed H, Ilas J, Saleh T, Abd-El-Aziz A
EXCLI J . 2017 Aug; 16:868-902. PMID: 28828001
The design of novel materials with significant biological properties is a main target in drug design research. Chromene compounds represent an interesting medicinal scaffold in drug replacement systems. This report...
17.
Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies
Rateb H, Ahmed H, Ahmed S, Ihmaid S, Afifi T
EXCLI J . 2017 Mar; 15:781-796. PMID: 28337109
In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives ( and ) were synthesized, fully characterized and evaluated...
18.
Design of New Benzo[h]chromene Derivatives: Antitumor Activities and Structure-Activity Relationships of the 2,3-Positions and Fused Rings at the 2,3-Positions
Okasha R, Alblewi F, Afifi T, Naqvi A, Fouda A, Al-Dies A, et al.
Molecules . 2017 Mar; 22(3). PMID: 28335470
A series of novel 4-benzo[]chromenes , -, , ; 7-benzo[]chromeno[2,3-]pyrimidines -, , and 14-benzo[]chromeno[3,2-][1,2,4]triazolo[1,5-]pyrimidine derivatives -, was prepared. The structures of the synthesized compounds were characterized on the basis of...
19.
Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure-activity relationships of the 1-aryl group and 9-position
Mohamed H, Fouda A, Khattab E, Agrody A, Afifi T
Z Naturforsch C J Biosci . 2016 Nov; 72(5-6):161-171. PMID: 27831925
A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring...
20.
Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives
Okasha R, Albalawi F, Afifi T, Fouda A, Al-Dies A, El-Agrody A
Molecules . 2016 Nov; 21(11). PMID: 27809292
Three new series of chromene molecules have been synthesized in order to explore their antimicrobial activity. The series encompass 2-substituted 14-(4-halophenyl)-12-methoxy-14-benzo[]chromeno[3,2-][1,2,4]-triazolo[1,5-]pyrimidines -, 9-benzylideneamino-7-(4-halo-phenyl)-5-methoxy-8-imino-7-benzo-[]chromeno[2,3-]pyrimidines - and 3-ethoxycarbonyl-14-(4-halophenyl)-12-methoxy-14-benzo-[]chromeno[3,2-][1,2,4]triazolo[1,5-]pyrimidine-2-one derivatives -. The structure...