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Ahmed Mora

Explore the profile of Ahmed Mora including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 13
Citations 425
Followers 0
Related Specialties
Biochemistry
Chemistry
Allergy & Immunology
Top 10 Co-Authors
Ahmed M El-Agrody
Ahmed M Fouda
Tarek H Afifi
Hany M Mohamed
Rawda M Okasha
Mohammed A A El-Nassag
Volker Henn
Ahmed A Elhenawy
Richard A Kroczek
Al-Anood M Al-Dies
Published In
Bioorg Chem
Front Immunol
Immunity
J Enzyme Inhib Med Chem
Int J Immunopathol Pharmacol
Affiliations
Soon will be listed here.
Recent Articles
1.
Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
El-Wahab A, Borik R, Al-Dies A, Fouda A, Mohamed H, El-Eisawy R, et al.
Sci Rep . 2024 Mar; 14(1):7589. PMID: 38555345
P-glycoprotein (P-gp) imparts multi-drug resistance (MDR) on the cancers cell and malignant tumor clinical therapeutics. We report a class of newly designed and synthesized oxygen-heterocyclic-based pyran analogues (4a-l) bearing different...
2.
MicroRNA-146a-5p and microRNA-210-3p Correlate with T Regulatory Cells Frequency and Predict Asthma Severity in Egyptian Pediatric Population
Eldosoky M, Hammad R, Rushdi A, Ibrahim H, Tawfeik A, Mora A, et al.
J Asthma Allergy . 2023 Jan; 16:107-121. PMID: 36714048
Background: Severe bronchial asthma (BA) affects 5-10% of children, which imposes socioeconomic burden. Therefore, it is crucial to identify biomarkers for risk stratification in children with BA. T regulatory cells...
3.
Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the -glycoprotein expression levels
Al-Harbi L, Al-Harbi E, Okasha R, El-Eisawy R, El-Nassag M, Mohamed H, et al.
J Enzyme Inhib Med Chem . 2023 Jan; 38(1):2155814. PMID: 36662632
A series of 1-benzo[]chromene moieties () were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules...
4.
Synthesis of 9-Hydroxy-1-Benzo[]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, -Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects
Albalawi F, El-Nassag M, El-Eisawy R, Mohamed M, Fouda A, Afifi T, et al.
Int J Mol Sci . 2023 Jan; 24(1). PMID: 36613493
-Enaminonitriles bearing 9-hydroxy-1-benzo[]chromene moiety was synthesized. The targeted compounds were evaluated for their anti-proliferative activity against three human tumor cell lines, PC-3, SKOV-3 and HeLa, and the active cytotoxic compounds...
5.
Frequency of CD4+ regulatory T cells, CD8+ T cells, and human papilloma virus infection in Egyptian Women with breast cancer
Tawfeik A, Mora A, Osman A, Moneer M, El-Sheikh N, Elrefaei M
Int J Immunopathol Pharmacol . 2020 Oct; 34:2058738420966822. PMID: 33103515
Several subsets of regulatory CD4+ T cells (CD4+ Tregs) have been described in peripheral blood and tumor microenvironment of breast cancer (BC) patients and may play a role in the...
6.
Novel molecular discovery of promising amidine-based thiazole analogues as potent dual Matrix Metalloproteinase-2 and 9 inhibitors: Anticancer activity data with prominent cell cycle arrest and DNA fragmentation analysis effects
Omar A, Bajorath J, Ihmaid S, Mohamed H, El-Agrody A, Mora A, et al.
Bioorg Chem . 2020 Jun; 101:103992. PMID: 32554279
Thiazole derivatives are known to possess various biological activities such as antiparasitic, antifungal, antimicrobial and antiproliferative activities. Matrix metalloproteinases (MMPs) are important protease target involved in tumor progression including angiogenesis,...
7.
A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules
Fouda A, Okasha R, Alblewi F, Mora A, Afifi T, El-Agrody A
Bioorg Chem . 2019 Dec; 95:103549. PMID: 31887476
In our endeavors to develop novel and powerful agents with antiproliferative activities, a series of β-enamionitriles, linked to the 8-bromo-1H-benzo[f]chromene moieties (4a-m), was designed and synthesized under microwave irradiation conditions....
8.
Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II
Fouda A, Assiri M, Mora A, Ali T, Afifi T, El-Agrody A
Bioorg Chem . 2019 Oct; 93:103289. PMID: 31586716
A novel series of halogenated β-enaminonitriles (4a-m), linked 9-bromo-1H-benzo[f]-hromene moieties, were synthesized via microwave irradiation and were predestined for their cytotoxic activity versus three cancer cell lines, namely: MCF-7, HCT-116,...
9.
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo[h]chromene
Alblewi F, Okasha R, Hritani Z, Mohamed H, El-Nassag M, Halawa A, et al.
Bioorg Chem . 2019 Apr; 87:560-571. PMID: 30928878
Novel β-enaminonitrile/ester compounds (4, 6) and an imidate of 4 (9) were utilized as key scaffolds for the synthesis of newly 2-substituted 4H-benzo[h]chromene (7, 8, 10, 11, 13, 14) and...
10.
Design and Synthesis of Novel Heterocyclic-Based 4-benzo[]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis
Alblewi F, Okasha R, Eskandrani A, Afifi T, Mohamed H, Halawa A, et al.
Molecules . 2019 Mar; 24(6). PMID: 30889862
Novel fused chromenes (,⁻) and pyrimidines (⁻) were designed, synthesized, and evaluated for their mammary gland breast cancer (MCF-7), human colon cancer (HCT-116), and liver cancer (HepG-2) activities. The structural...