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» Authors » Tarek H Afifi

Tarek H Afifi

Explore the profile of Tarek H Afifi including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 133
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Rawda M Okasha
Ahmed M Fouda
Ahmed M El-Agrody
Fawzia F Alblewi
Hany E A Ahmed
Ahmed Mora
Al-Anood M Al-Dies
Alaa S Abd-El-Aziz
Arshi Naqvi
Mosa H Alsehli
Published In
Bioorg Chem
Molecules
Int J Mol Sci
EXCLI J
Chem Commun (Camb)
Affiliations
Soon will be listed here.
Recent Articles
1.
Synthesis and Characterization of a New Class of Chromene-Azo Sulfonamide Hybrids as Promising Anticancer Candidates with the Exploration of Their EGFR, CAII, and MMP-2 Inhibitors Based on Molecular Docking Assays
Alblewi F, Alsehli M, Hritani Z, Eskandrani A, Alsaedi W, Alawad M, et al.
Int J Mol Sci . 2023 Dec; 24(23). PMID: 38069037
In this study, novel selective antitumor compounds were synthesized based on their fundamental pharmacophoric prerequisites associated with EGFR inhibitors. A molecular hybridization approach was employed to design and prepare a...
2.
Synthesis of 9-Hydroxy-1-Benzo[]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, -Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects
Albalawi F, El-Nassag M, El-Eisawy R, Mohamed M, Fouda A, Afifi T, et al.
Int J Mol Sci . 2023 Jan; 24(1). PMID: 36613493
-Enaminonitriles bearing 9-hydroxy-1-benzo[]chromene moiety was synthesized. The targeted compounds were evaluated for their anti-proliferative activity against three human tumor cell lines, PC-3, SKOV-3 and HeLa, and the active cytotoxic compounds...
3.
DFT and Investigations, along with Antitumor and Antimicrobial Assessments of Pharmacological Molecules
Alsehli M, Seth D, El-Gaby M, Okasha R, Hagar M, Afifi T, et al.
Curr Org Synth . 2022 Sep; 20(5):523-545. PMID: 36100991
Background: Molecules bearing an active methylene bridge are one of the most fruitful and remarkable precursors that have been incorporated into the synthetic strategy of an assortment of bioactive compounds....
4.
Development of Polyvinyl Alcohol/Kaolin Sponges Stimulated by Marjoram as Hemostatic, Antibacterial, and Antioxidant Dressings for Wound Healing Promotion
Tamer T, Alsehli M, Omer A, Afifi T, Sabet M, Mohy-Eldin M, et al.
Int J Mol Sci . 2021 Dec; 22(23). PMID: 34884855
The predominant impediments to cutaneous wound regeneration are hemorrhage and bacterial infections that lead to extensive inflammation with lethal impact. We thus developed a series of composite sponges based on...
5.
Novel 2-Hydroselenonicotinonitriles and Selenopheno[2, 3-b]pyridines: Efficient Synthesis, Molecular Docking-DFT Modeling, and Antimicrobial Assessment
Abdellattif M, Abdel-Rahman A, Arief M, Mouneir S, Ali A, Hussien M, et al.
Front Chem . 2021 May; 9:672503. PMID: 34041224
Selenium containing heterocyclic compounds gained great interest as bioactive molecules as of late. This report explores the design, synthesis, characterization, and antimicrobial screening of new pyridine derivatives endowed with selenium...
6.
A New Family of Benzo[]Chromene Based Azo Dye: Synthesis, In-Silico and DFT Studies with In Vitro Antimicrobial and Antiproliferative Assessment
Abd-El-Aziz A, Alsaggaf A, Assirey E, Naqvi A, Okasha R, Afifi T, et al.
Int J Mol Sci . 2021 Apr; 22(6). PMID: 33802075
The high biological activity of the chromene compounds coupled with the intriguing optical features of azo chromophores prompted our desire to construct novel derivatives of chromene incorporating azo moieties 4a-l,...
7.
Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B
Omar A, Alswah M, Ahmed H, Bayoumi A, El-Gamal K, El-Morsy A, et al.
Bioorg Chem . 2020 Feb; 96:103656. PMID: 32062449
A novel series of [1,2,4]triazolo[4,3-a]quinoxaline derivatives of different heteroaromatization members were synthesized. The newly synthesized molecules were explored for their potential antimicrobial activities against a panel of pathogenic organisms. Among...
8.
Synthesis, Biological Assessment, and Structure Activity Relationship Studies of New Flavanones Embodying Chromene Moieties
Assirey E, Alsaggaf A, Naqvi A, Moussa Z, Okasha R, Afifi T, et al.
Molecules . 2020 Feb; 25(3). PMID: 32012737
Novel flavanones that incorporate chromene motifs are synthesized via a one-step multicomponent reaction. The structures of the new chromenes are elucidated by using IR, H-NMR, C-NMR, H-H COSY, HSQC, HMBC,...
9.
A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules
Fouda A, Okasha R, Alblewi F, Mora A, Afifi T, El-Agrody A
Bioorg Chem . 2019 Dec; 95:103549. PMID: 31887476
In our endeavors to develop novel and powerful agents with antiproliferative activities, a series of β-enamionitriles, linked to the 8-bromo-1H-benzo[f]chromene moieties (4a-m), was designed and synthesized under microwave irradiation conditions....
10.
Microwave synthesis of novel halogenated β-enaminonitriles linked 9-bromo-1H-benzo[f]chromene moieties: Induces cell cycle arrest and apoptosis in human cancer cells via dual inhibition of topoisomerase I and II
Fouda A, Assiri M, Mora A, Ali T, Afifi T, El-Agrody A
Bioorg Chem . 2019 Oct; 93:103289. PMID: 31586716
A novel series of halogenated β-enaminonitriles (4a-m), linked 9-bromo-1H-benzo[f]-hromene moieties, were synthesized via microwave irradiation and were predestined for their cytotoxic activity versus three cancer cell lines, namely: MCF-7, HCT-116,...