Tara R Richman
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Explore the profile of Tara R Richman including associated specialties, affiliations and a list of published articles.
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20
Citations
600
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Recent Articles
1.
Richman T, Ermer J, Baker J, Siira S, Kile B, Linden M, et al.
Cell Rep
. 2023 Oct;
42(11):113312.
PMID: 37889747
Platelets are anucleate blood cells that contain mitochondria and regulate blood clotting in response to injury. Mitochondria contain their own gene expression machinery that relies on nuclear-encoded factors for the...
2.
Rossetti G, Ermer J, Stentenbach M, Siira S, Richman T, Milenkovic D, et al.
Sci Adv
. 2021 Sep;
7(39):eabi7514.
PMID: 34559558
Mitochondrial energy metabolism plays an important role in the pathophysiology of insulin resistance. Recently, a missense N437S variant was identified in the gene, which encodes a mitochondrial RNA processing enzyme...
3.
Richman T, Ermer J, Siira S, Kuznetsova I, Brosnan C, Rossetti G, et al.
Aging Cell
. 2021 Jun;
20(7):e13408.
PMID: 34096683
Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat...
4.
Perks K, Ferreira N, Ermer J, Rudler D, Richman T, Rossetti G, et al.
Aging (Albany NY)
. 2020 Oct;
12(19):19677-19700.
PMID: 33024056
The contribution of dysregulated mitochondrial gene expression and consequent imbalance in biogenesis is not well understood in metabolic disorders such as insulin resistance and obesity. The ribosomal RNA maturation protein...
5.
Rudler D, Hughes L, Perks K, Richman T, Kuznetsova I, Ermer J, et al.
Sci Adv
. 2020 Jan;
5(12):eaay2118.
PMID: 31903419
Mammalian mitochondrial ribosomes are unique molecular machines that translate 11 leaderless mRNAs; however, it is not clear how mitoribosomes initiate translation, since mitochondrial mRNAs lack untranslated regions. Mitochondrial translation initiation...
6.
Ferreira N, Perks K, Rossetti G, Rudler D, Hughes L, Ermer J, et al.
EMBO J
. 2019 Nov;
38(24):e102155.
PMID: 31721250
Translation fidelity is crucial for prokaryotes and eukaryotic nuclear-encoded proteins; however, little is known about the role of mistranslation in mitochondria and its potential effects on metabolism. We generated yeast...
7.
Viola H, Johnstone V, Cserne Szappanos H, Richman T, Tsoutsman T, Filipovska A, et al.
JACC Basic Transl Sci
. 2018 Sep;
1(1-2):61-72.
PMID: 30167506
Heterozygous mice ( ) expressing the human disease-causing mutation exhibit cardinal features of hypertrophic cardiomyopathy (HCM) including hypertrophy, myocyte disarray, and increased myocardial fibrosis. Treatment of mice with the L-type...
8.
Siira S, Rossetti G, Richman T, Perks K, Ermer J, Kuznetsova I, et al.
EMBO Rep
. 2018 Aug;
19(10).
PMID: 30126926
The molecular roles of the dually targeted ElaC domain protein 2 (ELAC2) during nuclear and mitochondrial RNA processing have not been distinguished. We generated conditional knockout mice of ELAC2 to...
9.
Wallis C, Richman T, Filipovska A, Rackham O
ACS Chem Biol
. 2018 May;
13(6):1499-1505.
PMID: 29808990
It has been widely shown that ligand-binding residues, by virtue of their orientation, charge, and solvent exposure, often have a net destabilizing effect on proteins that is offset by stability...
10.
Lake N, Webb B, Stroud D, Richman T, Ruzzenente B, Compton A, et al.
Am J Hum Genet
. 2018 Apr;
102(4):713.
PMID: 29625026
No abstract available.