Tapas K Das Gupta
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Explore the profile of Tapas K Das Gupta including associated specialties, affiliations and a list of published articles.
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40
Citations
687
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Recent Articles
1.
Mander S, Gorman G, Coward L, Christov K, Green A, Das Gupta T, et al.
Neurooncol Adv
. 2023 May;
5(1):vdad042.
PMID: 37197737
Background: Brain metastases (BMs), the most common tumors of the central nervous system, are life-threatening with a dismal prognosis. The major challenges to developing effective treatments for BMs are the...
2.
Choi J, Naffouje S, Goto M, Wang J, Christov K, Rademacher D, et al.
Commun Biol
. 2023 Jan;
6(1):16.
PMID: 36609683
Microorganisms living at many sites in the human body compose a complex and dynamic community. Accumulating evidence suggests a significant role for microorganisms in cancer, and therapies that incorporate bacteria...
3.
Mander S, Naffouje S, Gao J, Li W, Christov K, Green A, et al.
Front Oncol
. 2022 Aug;
12:940001.
PMID: 35936749
Despite recent advances in cancer research, glioblastoma multiforme (GBM) remains a highly aggressive brain tumor as its treatment options are limited. The current standard treatment includes surgery followed by radiotherapy...
4.
Naffouje S, Goto M, Coward L, Gorman G, Christov K, Wang J, et al.
J Med Chem
. 2022 May;
65(10):7371-7379.
PMID: 35544687
Precise identification of the tumor margins during breast-conserving surgery (BCS) remains a challenge given the lack of visual discrepancy between malignant and surrounding normal tissues. Therefore, we developed a fluorescent...
5.
Goto M, Ryoo I, Naffouje S, Mander S, Christov K, Wang J, et al.
EBioMedicine
. 2022 Feb;
76:103850.
PMID: 35108666
Background: Given the lack of visual discrepancy between malignant and surrounding normal tissue, current breast conserving surgery (BCS) is associated with a high re-excision rate. Due to the increasing cases...
6.
Naffouje S, Goto M, Ryoo I, Green A, Das Gupta T, Yamada T
Methods Mol Biol
. 2022 Jan;
2394:857-865.
PMID: 35094362
Precise surgical resection directly influences the prognosis and survival of patients with solid tumors. However, it is often difficult to distinguish tumor from normal tissue during resection without any intraoperative...
7.
Yamada T, Das Gupta T, Beattie C
Cancer Res
. 2016 Feb;
76(8):2354-65.
PMID: 26921335
p28 is an anionic cell-penetrating peptide of 28 amino acids that activates wild-type and mutated p53, leading subsequently to selective inhibition of CDK2 and cyclin A expression and G2-M cell-cycle...
8.
Yamada T, Das Gupta T, Beattie C
Mol Pharm
. 2013 Aug;
10(9):3375-83.
PMID: 23952735
p28, a cell penetrating peptide, binds to the DNA binding domain (DBD) of p53, inducing a post-translational increase in intracellular levels of wild type and mutant p53 activating pathways that...
9.
Turner A, Li L, Pilli T, Qian L, Wiley E, Setty S, et al.
PLoS One
. 2013 Mar;
8(2):e56817.
PMID: 23457619
The Map kinase Activating Death Domain containing protein (MADD) isoform of the IG20 gene is over-expressed in different types of cancer tissues and cell lines and it functions as a...
10.
Mehta R, Yamada T, Taylor B, Christov K, King M, Majumdar D, et al.
Angiogenesis
. 2011 Jun;
14(3):355-69.
PMID: 21667138
Amino acids 50-77 (p28) of azurin, a 128 aa cupredoxin isolated from Pseudomonas aeruginosa, is essentially responsible for azurin's preferential penetration of cancer cells. We now report that p28 also...