Tao-Hsin Chang
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Explore the profile of Tao-Hsin Chang including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
564
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0
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Recent Articles
1.
Hillier J, Zhao Y, Carrique L, Malinauskas T, Ruza R, Chang T, et al.
Nat Commun
. 2024 Aug;
15(1):7228.
PMID: 39174501
The Wnt receptor Frizzled3 (FZD3) is important for brain axonal development and cancer progression. We report structures of FZD3 in complex with extracellular and intracellular binding nanobodies (Nb). The crystal...
2.
Zhu N, Smallwood P, Rattner A, Chang T, Williams J, Wang Y, et al.
J Biol Chem
. 2024 Apr;
300(5):107283.
PMID: 38608728
Over the past 3 decades, a diverse collection of small protein domains have been used as scaffolds to generate general purpose protein-binding reagents using a variety of protein display and...
3.
Hsieh F, Chang T
Methods Mol Biol
. 2023 Jul;
2681:373-382.
PMID: 37405659
Antibodies are the major components of adaptive immunity for the recognition of diverse antigens. Six complementarity-determining regions (CDRs) from each heavy chain and light chain present the antigen-binding site, which...
4.
Hsieh F, Chang T, Gabelli S, Nathans J
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2217096120.
PMID: 37155902
Diverse extracellular proteins negatively regulate WNT signaling. One such regulator is adenomatosis polyposis coli down-regulated 1 (APCDD1), a conserved single-span transmembrane protein. In response to WNT signaling in a variety...
5.
Chang T, Hsieh F, Gu X, Smallwood P, Kavran J, Gabelli S, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(14):e2221103120.
PMID: 36996108
In many organs, small openings across capillary endothelial cells (ECs) allow the diffusion of low-molecular weight compounds and small proteins between the blood and tissue spaces. These openings contain a...
6.
Chang T, Hsieh F, Smallwood P, Gabelli S, Nathans J
Proc Natl Acad Sci U S A
. 2020 Jun;
117(26):15104-15111.
PMID: 32541044
Five small protein domains, the CC-domains, at the N terminus of the RECK protein, play essential roles in signaling by WNT7A and WNT7B in the context of central nervous system...
7.
Chang T, Hsieh F, Zebisch M, Harlos K, Elegheert J, Jones E
Elife
. 2015 Jul;
4.
PMID: 26158506
Wnt signalling regulates multiple processes including angiogenesis, inflammation, and tumorigenesis. Norrin (Norrie Disease Protein) is a cystine-knot like growth factor. Although unrelated to Wnt, Norrin activates the Wnt/β-catenin pathway. Signal...
8.
Kakugawa S, Langton P, Zebisch M, Howell S, Chang T, Liu Y, et al.
Nature
. 2015 Mar;
519(7542):187-192.
PMID: 25731175
Signalling by Wnt proteins is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved...
9.
Chang T, Chang S, Hsieh F, Ko T, Lin C, Ho M, et al.
PLoS Pathog
. 2013 Aug;
9(8):e1003563.
PMID: 23990784
Vaccinia virus envelope protein A27 has multiple functions and is conserved in the Orthopoxvirus genus of the poxvirus family. A27 protein binds to cell surface heparan sulfate, provides an anchor...
10.
Chang C, Teng K, Lin S, Chang T, Liang P
Biochemistry
. 2013 Mar;
52(16):2783-92.
PMID: 23534508
Previously we showed that yeast geranylgeranyl diphosphate synthase (GGPPS) becomes an inactive monomer when the first N-terminal helix involved in dimerization is deleted. This raises questions regarding why dimerization is...