Tanmaya Pathak
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Explore the profile of Tanmaya Pathak including associated specialties, affiliations and a list of published articles.
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49
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105
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Recent Articles
1.
Pan R, Dasgupta S, Pathak T
Org Biomol Chem
. 2025 Jan;
23(6):1457-1465.
PMID: 39760170
The "catalytic triad" present at the active site of ribonuclease A (RNase A) is responsible for the cleavage of the 5'-phosphodiester bond; amino acid residues His12, Lys41 and His119 constituting...
2.
Pathak T, Bose A
Carbohydr Res
. 2024 Jun;
541:109126.
PMID: 38823061
In general, 1,5-disubstituted 1,2,3-triazolyl moiety is much less common in the synthesis and applications in comparison to its regioisomeric counterpart. Moreover, the synthesis of 1,5-disubstituted 1,2,3-triazoles are not so straightforward...
3.
Mondal P, Dasgupta S, Pathak T
Bioorg Med Chem
. 2022 Nov;
76:117065.
PMID: 36436488
Molecular docking of N-1,4-disubstituted-1,2,3-triazole tethered carboxymethylated thymidine and uridine with ribonuclease A, indicated their possible binding with the P, B and P subsites with varied efficiencies. This theoretical study in...
4.
Das A, Dasgupta S, Pathak T
Bioorg Med Chem
. 2022 Aug;
71:116888.
PMID: 35944385
Ribonuclease A is used as a model enzyme system for the design of RNase inhibitors. Previous studies have established that the geometric nature of the active site cleft is an...
5.
Bose A, Pathak T
Adv Carbohydr Chem Biochem
. 2020 Dec;
78:1-134.
PMID: 33276909
Increasing demands for molecules with skeletal complexity, including those of stereochemical diversity, require new synthetic strategies. Carbohydrates have been used extensively as chiral building blocks for the synthesis of various...
6.
Das A, Dasgupta S, Pathak T
Org Biomol Chem
. 2020 Aug;
18(32):6340-6356.
PMID: 32766618
Seven new carbohydrate-bistriazole hybrid molecules were designed taking into consideration the crescent shaped active site of ribonuclease A (RNase A). In this case, the β-d-ribofuranose structure was used as the...
7.
Das A, Bhaumik A, Pathak T
Carbohydr Res
. 2019 Nov;
487:107870.
PMID: 31783289
The strained epoxide ring of oxirane-derived furanoside and pyranoside of d-fructose are regioselectively opened by various primary and secondary amines as well as azide to yield C4-alkylamino-C4-deoxy and the corresponding...
8.
Das J, Dey S, Pathak T
J Org Chem
. 2019 Oct;
84(23):15437-15447.
PMID: 31657567
A metal-free alternative to the regioselective synthesis of carboxylated 1,4-disubstituted 1,2,3-triazoles (1,4-cDTs) has been accomplished. A methoxycarbonyl-substituted vinyl sulfone on reactions with organic azides resulted in the formation of 1,4-cDTs...
9.
Datta D, Dasgupta S, Pathak T
Org Biomol Chem
. 2019 Jul;
17(30):7215-7221.
PMID: 31322157
Sulfonic nucleic acids were identified as inhibitors of ribonuclease A (RNase A). The incorporation of a strongly acidic group (sulfonic, -SOH) at the 3'-end of pyrimidine nucleosides thymidine and uridine...
10.
Kayet A, Datta D, Das A, Dasgupta S, Pathak T
Bioorg Med Chem
. 2017 Dec;
26(2):455-462.
PMID: 29258713
1,5-Regioisomeric triazole linked disaccharides have been synthesized and screened for their inhibitory properties against ribonuclease A (RNase A). The angular constraint-driven 'crescent shaped' inhibitors accommodated themselves into the enzyme active...