Tanja Holland
Overview
Explore the profile of Tanja Holland including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
144
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0
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Recent Articles
1.
Rademacher T, Sack M, Blessing D, Fischer R, Holland T, Buyel J
Plant Biotechnol J
. 2019 Jan;
17(8):1560-1566.
PMID: 30672078
Industrial plant biotechnology applications include the production of sustainable fuels, complex metabolites and recombinant proteins, but process development can be impaired by a lack of reliable and scalable screening methods....
2.
Fischer R, Holland T, Sack M, Schillberg S, Stoger E, Twyman R, et al.
Adv Biochem Eng Biotechnol
. 2018 Aug;
175:137-166.
PMID: 30069741
Most secreted proteins in eukaryotes are glycosylated, and after a number of common biosynthesis steps the glycan structures mature in a species-dependent manner. Therefore, human therapeutic proteins produced in plants...
3.
Menzel S, Holland T, Boes A, Spiegel H, Fischer R, Buyel J
Protein Expr Purif
. 2018 Jul;
152:122-130.
PMID: 30059744
Plants as a platform for recombinant protein expression are now economically comparable to well-established systems, such as microbes and mammalian cells, thanks to advantages such as scalability and product safety....
4.
Holland T, Buyel J
Methods Mol Biol
. 2017 Sep;
1674:129-146.
PMID: 28921434
Recombinant glycoproteins such as monoclonal antibodies have a major impact on modern healthcare systems, e.g., as the active pharmaceutical ingredients in anticancer drugs. A specific glycan profile is often necessary...
5.
Houdelet M, Galinski A, Holland T, Wenzel K, Schillberg S, Buyel J
Biotechnol J
. 2017 Feb;
12(4).
PMID: 28221723
Transient expression systems allow the rapid production of recombinant proteins in plants. Such systems can be scaled up to several hundred kilograms of biomass, making them suitable for the production...
6.
Santos R, Abranches R, Fischer R, Sack M, Holland T
Front Plant Sci
. 2016 Mar;
7:297.
PMID: 27014320
Plant cell suspension cultures have several advantages that make them suitable for the production of recombinant proteins. They can be cultivated under aseptic conditions using classical fermentation technology, they are...
7.
Menzel S, Holland T, Boes A, Spiegel H, Bolzenius J, Fischer R, et al.
Front Plant Sci
. 2016 Mar;
7:159.
PMID: 26925077
Plants provide an advantageous expression platform for biopharmaceutical proteins because of their low pathogen burden and potential for inexpensive, large-scale production. However, the purification of target proteins can be challenging...
8.
Meier K, Djeljadini S, Regestein L, Buchs J, Carstensen F, Wessling M, et al.
Biotechnol Prog
. 2014 Sep;
30(6):1348-55.
PMID: 25202924
Heterogeneities occur in various bioreactor designs including cell retention devices. Whereas in external devices changing environmental conditions cannot be prevented, cells are retained in their optimal environment in internal devices....
9.
Holland T, Blessing D, Hellwig S, Sack M
Biotechnol J
. 2013 Sep;
8(10):1231-40.
PMID: 24039008
Radio frequency impedance spectroscopy (RFIS) is a robust method for the determination of cell biomass during fermentation. RFIS allows non-invasive in-line monitoring of the passive electrical properties of cells in...